Cervical cord area measurement using volumetric brain magnetic resonance imaging in multiple sclerosis
Cervical cord area measurement using volumetric brain magnetic resonance imaging in multiple sclerosis
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DOI：
10.1016/j.msard.2014.11.004
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发表时间：
2015-01-01
影响因子：
4
通讯作者：
Chard, Declan T.
中科院分区：
文献类型：
--
作者：
Liu, Zheng;Yaldizli, Ozgur;Chard, Declan T.
背景：在多发性硬化症（MS）中，最近的研究表明，颈髓萎缩与身体残疾的相关性比脑白质病变负荷和萎缩的相关性更一致。尽管在许多临床试验和研究中并未常规获得脊髓成像，但脑体积成像通常具有并包括上颈髓。目标：使用体积 T1 加权脑图像，我们研究了最上颈髓的横截面积测量值，并将其与标准 C2/3 水平的面积进行比较。方法：使用 13 名对照者和 37 名多发性硬化症患者的 T1 加权脑部扫描，以及活性表面技术，测量的横截面积超过 5 毫米和 1 毫米。毫米绳段位于 C2/3，齿状突水平下方，脑桥下方 2 厘米和 2.5 厘米。还测量了脑体积。结果：脑桥下方 2.5 厘米的 5 毫米段的脊髓面积测量最可靠（评估者间变异系数 1.5%，组内相关系数 0.99）。该水平的脊髓面积与 C2/3 区域的相关性大于与脑体积的相关性（C2/3 的 r=0.811，与脑体积的 r=0.502）。结论：虽然标准 C2/3 水平通常不在脑图像的视野内，但脑桥下方 2.5 cm 的水平通常在视野内，并且当只有脑图像可用时，在该水平进行测量可能是研究上颈髓萎缩的好方法。 (C) 2014 Elsevier B.V. 保留所有权利。
Background: In multiple sclerosis (MS), recent work suggests that cervical cord atrophy is more consistently correlated with physical disability than brain white matter lesion load and atrophy. Although spinal cord imaging has not been routinely obtained in many clinical trial and research studies, brain volumetric imaging usually has and includes the upper cervical cord.Objectives: Using volumetric T1-weighted brain images, we investigated cross-sectional area measures in the uppermost cervical cord and compared them with areas at the standard C2/3 level.Methods: Using T1-weighted brain scans from 13 controls and 37 people with MS, and an active surface technique, cross-sectional area was measured over 5 mm and 1 mm cord segments at C2/3, below the level of odontoid peg, and 2 cm and 2.5 cm below the pons. Brain volume was also measured.Results: Cord area measurements were most reliable in a 5 mm segment 2.5 cm below the pons (inter-rater coefficient of variation 1.5%, intraclass correlation coefficient 0.99). Cord area at this level correlated more with that at C2/3 area than with brain volume (r=0.811 with C2/3, r=0.502 with brain volume).Conclusion: Whereas the standard C2/3 level is often not within the field of view on brain images, the level 2.5 cm below the pons usually is, and measurement at this level may be a good way to investigate upper cervical cord atrophy when only brain images are available. (C) 2014 Elsevier B.V. All rights reserved.