Vascular inflammation and endothelial dysfunction in experimental hypertension.
Vascular inflammation and endothelial dysfunction in experimental hypertension.
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DOI：
10.4061/2011/281240
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发表时间：
2011
影响因子：
1.9
通讯作者：
Volpe M
中科院分区：
文献类型：
--
作者：
Savoia C;Sada L;Zezza L;Pucci L;Lauri FM;Befani A;Alonzo A;Volpe M
原发性高血压的特征是外周血管对血流的阻力增加。内皮是血管张力的重要调节器。其功能在高血压患者中受损，血管舒张减少，血管张力增加，与促炎症和促血栓形成状态相关。因此，血管组织中的低度炎症被认为是高血压病理生理学、动脉粥样硬化的起始和进展以及心血管疾病发展的重要贡献者。
Essential hypertension is characterized by increased peripheral vascular resistance to blood flow. The endothelium is a crucial regulator of vascular tone. Its function is impaired in patients with hypertension, with reduced vasodilation, increased vascular tone associated with a proinflammatory and prothrombotic state. Low-grade inflammation localized in vascular tissue is therefore recognized as an important contributor to the pathophysiology of hypertension, to the initiation and progression of atherosclerosis as well as to the development of cardiovascular diseases.