Amelioration of Experimental Autoimmune Encephalomyelitis by Isogarcinol Extracted from Garcinia mangostana L. Mangosteen
Amelioration of Experimental Autoimmune Encephalomyelitis by Isogarcinol Extracted from Garcinia mangostana L. Mangosteen
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DOI：
10.1021/acs.jafc.6b04145
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发表时间：
2016-11-30
影响因子：
6.1
通讯作者：
Wei, Qun
中科院分区：
文献类型：
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作者：
Wang, Mengqi;Xie, Yufei;Wei, Qun
异藤黄酚是从山竹中提取的一种新型天然免疫抑制剂。在我们的实验室里。关于其对可治疗疾病的影响及其作用机制的知识仍然非常有限。在这项研究中，我们探讨了异儿茶酚在实验性自身免疫性脑脊髓炎（EAE），多发性硬化（MS）的小鼠模型的治疗作用。口服100 mg/kg异甘草酸治疗可显著改善EAE小鼠的临床评分，减轻脊髓炎症和脱髓鞘，并减少颅内病变。Th细胞和巨噬细胞的百分比也显著降低。异Garcinol似乎通过抑制辅助性T细胞（Th）1和Th 17细胞分化，通过Janus激酶/信号转导子和转录途径的激活子，并通过损害巨噬细胞功能。我们的数据表明，异儿茶酚有可能成为一种有效的治疗剂，低毒性治疗MS和其他自身免疫性疾病。
Isogarcinol is a new natural immunosuppressant that was extracted from Garcinia mangostana L. in our laboratory. Knowledge of its effects on treatable diseases and its mechanism of action is still very limited. In this study, we explored the therapeutic effect of isogarcinol in experimental autoimmune encephalomyelitis (EAE), a murine model of multiple sclerosis (MS). Treatment with oral 100 mg/kg isogarcinol markedly ameliorated clinical scores, alleviated inflammation and demyelination of the spinal cord, and reduced intracranial lesions in EAE mice. The percentages of Th cells and macrophages were also strongly reduced. Isogarcinol appeared to act by inhibiting T helper (Th) 1 and Th17 cell differentiation via the janus kinase/signal transducers and activators of transcription pathway and by impairing macrophage function. Our data suggest that isogarcinol has the potential to be an effective therapeutic agent of low toxicity for treating MS and other autoimmune diseases.