Considerations on joint and articular cartilage mechanics
Considerations on joint and articular cartilage mechanics
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DOI：
10.1007/s10237-006-0029-y
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发表时间：
2006-06-01
影响因子：
3.5
通讯作者：
Federico, S.
中科院分区：
文献类型：
--
作者：
Herzog, W.;Federico, S.
在研究导致骨关节炎（OA）的关节退行性变时，似乎必须在正常的日常运动中了解局部关节组织负荷，并系统地量化这种负荷的适应性/退行性影响。从哲学上讲，我们认为解决这个问题的最佳方法是通过长期实验模型研究关节退行性变和骨关节炎，并通过精确的几何和结构理论模型来代表diarthrodial关节和相关组织。在这里，我们提出了我们的工作代表这种方法的一些例子。在实验上，我们证明了OA实验模型中关节的局部载荷不断变化，不仅是因为外部和内部载荷的变化，而且还因为关节接触几何形状和组织力学特性的连续变化。此外，我们表明，单回合的关节负荷影响基因表达，基因表达，以及随后的关节退化是位点特异性的。事实上，暴露于相同载荷的相对关节面可能以完全不同的速率退化。最后，我们提出了一系列的关节软骨和接触力学的理论模型，证明了许多各向异性和不均匀的属性可以解释的结构元素和它们的方向和体积浓度在整个组织。
When studying joint degeneration leading to osteoarthritis (OA), it seems imperative that local joint tissue loading is known during normal everyday movement and that the adaptive/degenerative effects of this loading are quantified systematically. Philosophically, we believe the best way to approach this problem is by studying joint degeneration and osteoarthritis in long-term experimental models and by representing diarthrodial joints and the associated tissues with accurate, geometric and structural, theoretical models. Here, we present selected examples of our work representing this approach. Experimentally, we demonstrate that the local loading of joints changes continuously in experimental models of OA, not only because of the changing external and internal loading, but also because of the continuous alterations in joint contact geometry and tissue mechanical properties. Furthermore, we show that single bouts of joint loading affect gene expression, and that gene expression, as well as subsequent joint degeneration is site-specific. In fact, opposing articular surfaces that are exposed to the same loading may degenerate at completely different rates. Finally, we propose a series of theoretical models of articular cartilage and contact mechanics, demonstrating that many of the anisotropic and inhomogeneous properties can be explained by structural elements and their orientation and volumetric concentration across the tissue.