EVIDENCE AGAINST ASSOCIATION BETWEEN PARITY AND NIDDM FROM 5 POPULATION GROUPS
EVIDENCE AGAINST ASSOCIATION BETWEEN PARITY AND NIDDM FROM 5 POPULATION GROUPS
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DOI：
10.2337/diacare.14.11.975
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发表时间：
1991-11-01
期刊：
影响因子：
16.2
通讯作者：
ZIMMET, PZ
中科院分区：
文献类型：
--
作者：
COLLINS, VR;DOWSE, GK;ZIMMET, PZ
目的：确定所报道的产次与非胰岛素依赖型糖尿病（NIDDM）和糖耐量受损（IGT）之间的正相关性是否在其他人群中重现。研究设计和方法：我们调查了四个太平洋和印度洋岛国基于人口的调查数据的关系。在调查时年龄大于或等于40岁的妇女，不包括那些在40岁之前患糖尿病的妇女，被纳入这项研究，其中包括瑙鲁（n = 204）和基里巴斯（n = 562），斐济美拉尼西亚人（n = 390），斐济印第安人（n = 247）和混合种族的斐济人（n = 1333）。受试者在每次调查进行了75克口服葡萄糖耐量试验，并确定葡萄糖耐量状态与1985年世界卫生组织的标准。通过访谈确定产科信息和糖尿病家族史。结果如下：年龄和体重指数（BMI）调整后的平均产次仅在两组中随葡萄糖耐量恶化而略有增加，一组下降，另两组不一致（均无统计学意义）。我们还发现足月妊娠的数量与IGT和NIDDM的患病率之间存在不一致的关系，尽管在每个人群中，与最低胎次组（1-3次妊娠）相比，最高胎次组（大于或等于10次妊娠）的NIDDM患病率较高。在Logistic回归分析中，考虑到年龄、BMI和糖尿病家族史，每次妊娠与NIDDM和IGT相关的比值比估计值并不显著大于1。结论：结果表明，在这些人群中，产次和糖耐量异常的发展之间几乎没有任何独立的联系。
Objective: To determine whether a reported positive association between parity and the development of non-insulin-dependent diabetes mellitus (NIDDM) and impaired glucose tolerance (IGT) is reproducible in other populations. Research Design and Methods: We investigated the relationship in data from population-based surveys in four Pacific and Indian Ocean island nations. Women greater-than-or-equal-to 40 yr of age at the time of the survey, excluding those in whom diabetes developed before 40 yr of age, were included in this study of Micronesians from Nauru (n = 204) and Kiribati (n = 562), Fiji Melanesians (n = 390), Fiji Indians (n = 247), and mixed-ethnic Mauritians (n = 1333). Subjects in each survey underwent a 75-g oral glucose tolerance test, and glucose tolerance status was ascertained with 1985 World Health Organization criteria. Obstetric information and family history of-diabetes were determined by interview. Results: Age and body mass index (BMI)-adjusted mean parity increased slightly with worsening glucose tolerance in only two groups, decreased in one group, and was inconsistent in the other two (none were statistically significant). We also found an inconsistent relationship between the number of full-term pregnancies and the prevalence of IGT and NIDDM, although in each population, there was a higher prevalence of NIDDM in the highest parity group (greater-than-or-equal-to 10 pregnancies) compared with the lowest parity group (1-3 pregnancies). In logistic regression analyses accounting for age, BMI, and family history of diabetes, odds ratio estimates for NIDDM and IGT associated with each pregnancy were not significantly greater than unity. Conclusions: The results indicate that there is little if any independent association between parity and the development of abnormal glucose tolerance in these populations.