Palladium-catalysed regioselective hydroamination of 1,3-dienes: synthesis of allylic amines
Palladium-catalysed regioselective hydroamination of 1,3-dienes: synthesis of allylic amines
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DOI：
10.1039/c4qo00023d
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发表时间：
2014-01-01
影响因子：
5.4
通讯作者：
Beller, Matthias
中科院分区：
文献类型：
--
作者：
Banerjee, Debasis;Junge, Kathrin;Beller, Matthias
未活化的1，3-二烯的催化氢胺化代表了可持续的和原子经济的C-N键形成过程。在这里，我们提出了一种新的催化体系组成的Pd（COD）Cl-2与DPEphos的选择性1，4-氢胺化（反马尔可夫尼科夫反应）的一系列无环和环状二烯。该反应以良好的产率进行，并且允许具有高区域选择性的烯丙基胺的排他性形成，并且不需要任何添加剂。
Catalytic hydroamination of unactivated 1,3-dienes represents a sustainable and atom-economic C-N bond forming process. Here, we present a novel catalytic system consisting of Pd(cod)Cl-2 in combination with DPEphos for the selective 1,4-hydroamination (anti-Markovnikov reaction) of a series of acyclic and cyclic dienes. The reactions proceed in good yields and allow for the exclusive formation of allylic amines with high regioselectivity and do not need any additives.