Molecular characterization and expression analysis of suppressors of cytokine signalling from golden pompano ( Trachinotus ovatus )
Molecular characterization and expression analysis of suppressors of cytokine signalling from golden pompano ( Trachinotus ovatus )
复制标题
金鲳（Trachinotus ovatus）细胞因子信号抑制因子的分子特征和表达分析
DOI：
10.1111/are.15470
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发表时间：
2021
影响因子：
2
通讯作者：
Zhitao Qi
中科院分区：
文献类型：
--
作者：
Ruifeng Qiao;Xie Yeyang;Yuhao Liu;Shuangshuang Gao;Xiaoxia Li;Jiang Li;Peng Zhu;Wei Youchuan;Zhitao Qi
The suppressors of cytokine signalling (SOCS) family plays negative roles in regulating cytokine signalling pathways that related to immunity, growth and development. In the present study, eight SOCS genes were characterized from golden pompano (Trachinotus ovatus), a marine teleost with great economic values. The eight SOCSs of golden pompano possess conserved motifs that found in other fish SOCSs. The obtained SOCSs shared high sequence identities with their counterparts in other fish species, confirmed by phylogenetic tree analysis. Quantitative real‐time PCR revealed that the eight SOCS genes were ubiquitously expressed in all the selected tissues of normal golden pompano. After lipopolysaccharide (LPS), polyI:C andVibrioalginilyticuschallengedin vivo, the SOCS genes of golden pompano exhibited distinct expression patterns in spleen and head kidney (HK). Our results indicated that SOCSs involve in the immune response to viral or bacterial infection in golden pompano. To the best of our knowledge, this is the first report on SOCSs in golden pompano.
