Palmitoylation and processing of the lipopeptide surfactant protein C.
Palmitoylation and processing of the lipopeptide surfactant protein C.
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DOI：
10.1016/s1388-1981(02)00248-2
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发表时间：
2002-08
期刊：
影响因子：
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通讯作者：
A. ten Brinke;L. V. van Golde;J. J. Batenburg-J.
中科院分区：
文献类型：
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作者：
A. ten Brinke;L. V. van Golde;J. J. Batenburg-J.
肺表面活性剂是一种脂质和蛋白质的混合物，通过形成表面活性膜来降低肺泡空气-水界面的表面张力。这样，它可以防止肺泡塌陷，促进呼吸工作。表面活性剂蛋白C （SP-C）在这一表面活性剂功能中起着重要作用。SP-C以蛋白质形式表达，翻译后被棕榈酸酯修饰，并经历多轮蛋白水解裂解。这导致成熟SP-C的形成，其储存在板层体（LB）中，最终分泌到肺泡空间。近年来，通过诱变研究，对褐藻酸c的分类、加工和棕榈酰化有了新的认识。此外，关于SP-C缺乏与肺部疾病发展相关的报道，使人们对SP-C对表面活性剂平衡的重要性有了新的认识。此外，SP-C的棕榈酰链在表面活性中的作用也有了新的认识。本文综述了近年来SP-C的加工和功能的研究进展，重点介绍了SP-C棕榈酰化的信号及其作用。
Pulmonary surfactant, a mixture of lipids and proteins, reduces the surface tension at the air–water interface of the lung alveoli by forming a surface active film. This way, it prevents alveoli from collapsing and facilitates the work of breathing. Surfactant protein C (SP-C) plays an important role in this surfactant function. SP-C is expressed as a proprotein (proSP-C), which becomes posttranslationally modified with palmitate and undergoes several rounds of proteolytical cleavage. This results in the formation of mature SP-C, which is stored in the lamellar bodies (LB) and finally secreted into the alveolar space. Recently, new insights into the sorting, processing and palmitoylation of proSP-C have been obtained by mutagenesis studies. Moreover, reports on the association of development of lung disease with SP-C deficiency have led to new insights into the importance of SP-C for proper surfactant homeostasis. In addition, new information has become available on the role of the palmitoyl chains of SP-C in surface activity. This review summarizes these recent developments in the processing and function of SP-C, with particular emphasis on the signals for and role of palmitoylation of SP-C.