Assessment of the variation of skin barrier function with anatomic site, age, gender and ethnicity
Assessment of the variation of skin barrier function with anatomic site, age, gender and ethnicity
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DOI：
10.1111/j.1468-2494.2010.00587.x
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发表时间：
2010-12-01
影响因子：
2.3
通讯作者：
Lane, M. E.
中科院分区：
文献类型：
--
作者：
Machado, M.;Hadgraft, J.;Lane, M. E.
皮肤是人体最大的器官，它的功能包括保护、体温调节、感觉和分泌。近年来，我们对皮肤形态和生理对皮肤屏障作用的理解取得了重大进展。本综述的目的是总结用于评估皮肤屏障功能随解剖部位、年龄、性别和种族变化的主要方法。讨论的方法包括经表皮水分损失（TEWL）测量，角质细胞大小评估，对血管活性化合物的反应以及皮肤的衰减全反射傅立叶变换红外（ATR-FTIR）检测。考虑了各种方法的效用，并强调了迄今为止文献中最重要的发现。
The skin is the largest organ of the human body and its functions include protection, thermoregulation sensation and secretion. Significant advances in our understanding of how the morphology and physiology of the skin contribute to the skin's barrier role have been achieved in recent years. The aim of this review is to summarize the principal approaches which have been used to assess variation in skin barrier function with anatomic site, age, gender, and ethnicity. The methods discussed include trans-epidermal water loss (TEWL) measurement, assessment of corneocyte size, response to vasoactive compounds and attenuated total reflectance Fourier transform infrared (ATR-FTIR) interrogation of skin. The utility of the various methods is considered and the most important findings in the literature to date are highlighted.