Correspondence
Correspondence
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DOI：
10.1016/0306-4522(96)00348-x
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发表时间：
1893-10
期刊：
影响因子：
--
通讯作者：
M. M. Syddiq-M.
中科院分区：
文献类型：
--
作者：
M. M. Syddiq-M.
在神经肌肉接头处记录的微型终板电位是由乙酰胆碱的量子释放引起的，并且诱发终板电位可以被描述为微型电位的整数倍。多种因素，包括突触后细胞上的多个突触的存在和树突过滤，复杂的中央突触的量子分析。在目前的调查大鼠海马脑片，递质释放被阻止，除了一个局部区域的CA 1神经元的顶树突和量子分析进行微型兴奋性突触后电流（mEPSC）和诱发的EPSC的低量子含量。结果表明，在这些条件下，α-氨基-3-羟基-5-甲基-4-异恶唑丙酸受体介导的mEPSC表现出正常的大小分布，SD值与神经肌肉接头处的那些相当，并且诱发的EPSC可以被描述为微型电流的整数倍。这些结果也支持文献中的报告，即长时程增强（LTP）与mEPSC频率增加有关。这种增加是由于（a）已经有功能的突触的量子释放增强，还是由于（B）附近沉默突触的募集，在那里可以忽略的递质释放变得可测量，或者功能受体簇被发现，目前还不能区分。
Miniature end-plate potentials recorded at the neuromuscular junction are caused by a quantal release of acetylcholine and evoked end-plate potentials can be described as integer multiples of the miniature potentials. A variety of factors including the presence of multiple synapses on postsynaptic cells and dendritic filtering, complicate quantal analyses at central synapses. In the present investigation on rat hippocampal slices, transmitter release was blocked except for a localized area on the apical dendrites of CA1 neurons and quantal analysis was performed on miniature excitatory postsynaptic currents (mEPSCs) and evoked EPSCs of low quantum content. The results indicate that under these conditions, alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor-mediated mEPSCs exhibit a normal size distribution with SD values comparable to those at the neuromuscular junction, and the evoked EPSCs can be described as integer multiples of the miniature currents. The results also support reports in literature that long-term potentiation (LTP) is associated with an increase in mEPSC frequency. Whether the increase is due to (a) the enhancement of quantal release at already functional synapses, or (b) the recruitment of nearby silent synapses where a neglible transmitter release becomes measurable, or clusters of functional receptors are uncovered, cannot yet be distinguished.