Preoperative histological grading of meningiomas using apparent diffusion coefficient at 3T MRI
Preoperative histological grading of meningiomas using apparent diffusion coefficient at 3T MRI
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DOI：
10.1016/j.ejrad.2012.11.037
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发表时间：
2013-04-01
影响因子：
3.3
通讯作者：
Kurisu, Kaoru
中科院分区：
文献类型：
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作者：
Watanabe, Yosuke;Yamasaki, Fumiyuki;Kurisu, Kaoru
目的：我们评估了B = 4000 s/mm（2）的高b值DWI是否可以区分脑膜瘤的肿瘤分级的组织病理学分化，并关注放射学特征与肿瘤分级之间的关系。材料和方法：我们对77例患者（分别为42例、31例和4例WHO I级（G1）、II级（G2）和III级（G3））在B = 1000和B = 4000 s/mm 2的3 T条件下采集DWI。表观扩散系数（ADC）通过在ADC图上放置多个感兴趣区域（ROI）来测量。每个肿瘤的ADC值在术前从几个ROI中确定，并表示为最小值（ADC（MIN））、平均值（ADC（MEAN））和最大绝对值（ADC（MAX））。我们评估了ADC值与组织学表现的关系，并评估了脑膜瘤的放射学特征，如肿瘤位置、肿瘤大小、有无瘤周水肿、肿瘤形状、有无骨质破坏或增生、增强状态、有无钙化和囊肿。根据判别分析的结果，表观对数似然值在B = 4000时ADC（MIN）最大。此外，当我们进行多因素Logistic回归分析时，发现只有B = 4000时的ADC（MIN）值与脑膜瘤的组织学分级显著相关，这些因素包括肿瘤的形状、有无骨质破坏、增强状态、有无囊肿以及B = 4000时的ADC（MIN）。一个脑膜瘤在高b值时具有低ADC值（MIN）可能意味着高级别脑膜瘤。(C)2012爱思唯尔爱尔兰有限公司保留所有权利。
Purpose: We assessed whether a high b-value DWI at b = 4000 s/mm(2) would discriminate the histopathological differentiation of the tumor grade of meningiomas, and also focused on the relationship between radiologic features and the tumor grade.Materials and methods: We acquired DWI at 3T with b = 1000 and b = 4000 s/mm2 in 77 patients (42, 31 and 4 patients were WHO grades I (G1), II (G2), and III (G3), respectively). The apparent diffusion coefficient (ADC) was measured by placing multiple regions of interest (ROIs) on ADC maps. The ADC values of each tumor were determined preoperatively from several ROIs, and expressed as the minimum (ADC(MIN)), mean (ADC(MEAN)), and maximum absolute values (ADC(MAX)). We evaluated the relationship between ADCs and histological findings, and assessed the radiologic features such as tumor location, tumor size, presence/absence of peritumoral edema, shape of the tumor, presence/absence of bone destruction or hyperplasia, status of contrast enhancement, presence/absence of calcification and cyst.Results: ADCs of the meningiomas were inversely correlated with the histological grade of meningiomas. According to results of the discriminant analysis, the apparent log likelihood value was greatest for ADC(MIN) at b = 4000. Furthermore, only the ADC(MIN) value at b = 4000 was significantly correlated with the histological grade of meningiomas when we performed a multiple logistic regression analysis to identify the significant independent factors such as shape of tumor, presence/absence of bone destruction, status of contrast enhancement, presence/absence of cyst and ADC(MIN) at b = 4000.Conclusion: A meningioma with a low ADC(MIN) at a high b-value might imply a high-grade meningioma. (C) 2012 Elsevier Ireland Ltd. All rights reserved.