Gene Expression Omnibus: NCBI gene expression and hybridization array data repository
Gene Expression Omnibus: NCBI gene expression and hybridization array data repository
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DOI：
10.1093/nar/30.1.207
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发表时间：
2002-01-01
影响因子：
14.9
通讯作者：
Lash, AE
中科院分区：
文献类型：
--
作者：
Edgar, R;Domrachev, M;Lash, AE
基因表达综合数据库（GEO）项目是为了满足对高通量基因表达数据公共存储库日益增长的需求而启动的。GEO提供了一个灵活和开放的设计，便于提交，存储和检索来自高通量基因表达和基因组杂交实验的异构数据集。GEO并不打算取代内部的基因表达数据库，这些数据库受益于连贯的数据集，并且其构建是为了促进特定的分析方法，而是通过充当三级中央数据分发中心来补充这些数据库。GEO的三个核心数据实体是平台、样本和系列，其设计考虑到了基因表达和基因组杂交实验。平台本质上是一个探针列表，它定义了可以检测到什么样的分子。样品描述了被探测的一组分子，并引用了用于生成其分子丰度数据的单个平台。一个系列将样本组织成有意义的数据集，这些数据集构成了一个实验。可通过万维网http://www.ncbi.nlm.nih.gov/geo公开查阅全球环境展望资料库。
The Gene Expression Omnibus (GEO) project was initiated in response to the growing demand for a public repository for high-throughput gene expression data. GEO provides a flexible and open design that facilitates submission, storage and retrieval of heterogeneous data sets from high-throughput gene expression and genomic hybridization experiments. GEO is not intended to replace in house gene expression databases that benefit from coherent data sets, and which are constructed to facilitate a particular analytic method, but rather complement these by acting as a tertiary, central data distribution hub. The three central data entities of GEO are platforms, samples and series, and were designed with gene expression and genomic hybridization experiments in mind. A platform is, essentially, a list of probes that define what set of molecules may be detected. A sample describes the set of molecules that are being probed and references a single platform used to generate its molecular abundance data. A series organizes samples into the meaningful data sets which make up an experiment. The GEO repository is publicly accessible through the World Wide Web at http://www.ncbi.nlm.nih.gov/geo.