Synthesis of 2H-Azirines by Iridium-Catalyzed Decarboxylative Ring Contraction of Isoxazol-5(4H)-ones
Synthesis of 2H-Azirines by Iridium-Catalyzed Decarboxylative Ring Contraction of Isoxazol-5(4H)-ones
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DOI：
10.1002/anie.201602241
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发表时间：
2016-06-13
影响因子：
16.6
通讯作者：
Ohe, Kouichi
中科院分区：
文献类型：
--
作者：
Okamoto, Kazuhiro;Shimbayashi, Takuya;Ohe, Kouichi
研究了铱催化的无膦异恶唑-5（4 H）-酮（异恶唑酮）的反应，通过脱羧和缩环得到2 H-氮杂环丙烷。该方法提供了一种高效且环境友好的方案，可以取代用于合成2 H-氮杂环丙烷的常规方法。
A phosphine-free iridium-catalyzed reaction of isoxazol-5(4H)-ones (isoxazolones) has been developed, and affords 2H-azirines through decarboxylation and ring contraction. This method provides an efficient and environmentally benign protocol which could replace the conventional approaches used to synthesize 2H-azirines.