Modification of the binding properties of muscarinic receptors by gallamine.
Modification of the binding properties of muscarinic receptors by gallamine.
复制标题
没食子胺改变毒蕈碱受体的结合特性。
作者：
J. Stockton;N. Birdsall;A. Burgen;E. Hulme
本文研究了不同组织中的毒蕈碱受体与没食子胺的相互作用。没食子胺与不同于常规毒蕈碱配体结合位点的位点结合，并调节激动剂和拮抗剂与常规结合位点的结合。与已报道的药理学研究一致，在心脏中，没食子胺对毒蕈碱配体结合的影响比在其他组织中大得多。这些研究结果表明，开发新的和选择性的毒蕈碱药物的可能性。
The interaction of gallamine with muscarinic receptors from different tissues has been investigated. Gallamine binds to a site distinct from the conventional muscarinic ligand binding site and modulates the binding of agonists and antagonists to the conventional binding site. In agreement with reported pharmacological studies, the effects of gallamine on the binding of muscarinic ligands are much greater in heart than in other tissues. These findings suggest the possibility of developing novel and selective muscarinic drugs.