Cantilever-based sensor for the detection of different chromophore isomers.
Cantilever-based sensor for the detection of different chromophore isomers.
复制标题
用于检测不同发色团异构体的悬臂传感器。
DOI：
10.1021/ac0703000
复制
发表时间：
2007
影响因子：
7.4
通讯作者：
Ivanisevic,Albena
中科院分区：
文献类型：
--
作者：
Flores-Perez,Rosangelly;Gupta,AmitK;Bashir,Rashid;Ivanisevic,Albena
我们报告了使用微电泳（MCs）检测三种维甲酸异构体：9-顺式-视黄醛，13-顺式-视黄醛和全反式-视黄醛。检测局部化妆品中的合成和天然类维生素A很重要，它们的存在可用于预测皮肤表面的反应。在这项研究中，MC表面功能化，以促进形成共价键与发色团。我们用官能化的MC检测到的最低质量偏移为1.2ppt，这在化妆品工业所需的范围内。我们的研究结果表明，适当设计和功能化的微悬臂梁可以用来构建经济，快速，灵敏的传感器，用于化妆品的质量控制。
We report the use of microcantilevers (MCs) for the detection of three retinoid isomers: 9-cis-retinal, 13-cis-retinal and all-trans-retinal. Detection of synthetic and natural retinoids in topical cosmetic products is important, and their presence can be used to predict reactions with the skin surface. In this study the MC surfaces were functionalized in order to promote the formation of covalent bonds with the chromophores. The lowest mass shift we detected with the functionalized MCs was 1.2 ppt, which is in the range needed by the cosmetics industry. Our results indicate that properly designed and functionalized microcantilevers can be used to construct economical, fast, and sensitive sensors for quality control in cosmetics.