Developmental changes of optical properties in neonates determined by near-infrared time-resolved spectroscopy
Developmental changes of optical properties in neonates determined by near-infrared time-resolved spectroscopy
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DOI：
10.1203/01.pdr.0000175638.98041.0e
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发表时间：
2005-09-01
影响因子：
3.6
通讯作者：
Itoh, S
中科院分区：
文献类型：
--
作者：
Ijichi, S;Kusaka, T;Itoh, S
近红外光谱已被用于测量婴儿脑血红蛋白浓度的变化，以研究脑氧合和血流动力学。本研究应用时间分辨光谱法（TRS）测定了22例新生儿的光吸收系数（μ s）、约化散射系数（g s）、脑血红蛋白氧饱和度（Sco（2））、脑血容量（CBV）和微分光程系数（DPF），并探讨了μ s、Sco（2）、CBV和DPF与孕后年龄的关系。一个便携式三波长TRS系统与探头连接到新生儿的头部被使用。新生儿在761、795和835 nm处的平均A值估计分别为（平均值+/- SD）6.46 +/- 1.21、5.90 +/- 1.15和6.40 +/- 1.16/cm。孕后年龄与[mu '（s）]呈显著正相关。在这三个波长。平均Sco（2）值计算为70.0 +/-4.6%，孕后年龄和Sco（2）呈负线性关系。CBV的平均值为2.31 +/- 0.56 mL/100 g。在761、795和835 nm处的平均DPF值估计分别为4.58 +/- 0.41、4.64 +/- 0.46和4.31 +/- 0.42。在这三个波长下，孕后年龄与DPF之间没有关系。结果表明，我们的近红外TRS方法可用于在重症监护病房床边监测新生儿脑中的μ '（s）、Sco（2）、CB V和DPF。
Near-infrared spectroscopy has been used for measurement of changes in cerebral Hb concentrations in infants to study cerebral oxygenation and hemodynamics. In this study, measurements by time-resolved spectroscopy (TRS) were performed in 22 neonates to estimate the values of light absorption coefficient and reduced scattering coefficient (g's), cerebral Hb oxygen saturation (Sco(2)), cerebral blood volume (CBV), and differential path-length factor (DPF), and the relationships between postconceptional age and mu's, SCo2, CBV, and DPF were investigated. A portable three-wavelength TRS system with a probe attached to the head of the neonate was used. The mean A's values at 761, 795, and 835 nm in neonates were estimated to be (mean +/- SD) 6.46 +/- 1.21, 5.90 +/- 1.15 and 6.40 +/- 1.16/cm, respectively. There was a significant positive relationship between postconceptional age and [mu'(s). at those three wavelengths. The mean Sco(2) value was calculated to be 70.0 +/- 4.6%, and postconceptional age and Sco(2) showed a negative linear relationship. The mean value of CBV was 2.31 +/- 0.56 mL/100 g. There was a significant positive relationship between postconceptional age and CBV.The mean DPF values at 761, 795, and 835 nm were estimated to be 4.58 +/- 0.41, 4.64 +/- 0.46, and 4.31 +/- 0.42, respectively. There was no relationship between postconceptional age and DPF at those three wavelengths. The results demonstrated that our near-infrared TRS method can be used to monitor mu'(s), Sco(2), CB V, and DPF in the neonatal brain at the bedside in an intensive care unit.