Red Blood Cell Function and Dysfunction: Redox Regulation, Nitric Oxide Metabolism, Anemia.
Red Blood Cell Function and Dysfunction: Redox Regulation, Nitric Oxide Metabolism, Anemia.
复制标题
DOI：
10.1089/ars.2016.6954
复制
发表时间：
2017-05-01
影响因子：
6.6
通讯作者：
Cortese-Krott MM
中科院分区：
文献类型：
--
作者：
Kuhn V;Diederich L;Keller TCS 4th;Kramer CM;Lückstädt W;Panknin C;Suvorava T;Isakson BE;Kelm M;Cortese-Krott MM
意义：最近的临床证据表明，贫血与心血管疾病（CVD）的严重并发症相关，如出血、血栓栓塞事件、中风、高血压、心律失常和炎症，特别是在老年患者中。这些并发症的潜在机制在很大程度上是未知的。最近的进展：以前，红细胞（rbc）被认为是氧气和营养物质到组织的转运体。最近的实验证据表明，红细胞是重要的器官间通讯系统，具有其他功能，包括参与控制全身一氧化氮代谢、氧化还原调节、血液流变学和粘度。在本文中，我们旨在修订和讨论红细胞的这些非规范功能及其在心血管系统和贫血中的功能障碍的潜在影响。关键问题：红细胞功能特性的改变与贫血相关心血管并发症之间的机制联系迄今尚未解开。未来方向：为了更好地理解CVD中与贫血相关的并发症，基础和转化科学研究应侧重于确定红细胞在心血管系统中的非规范功能的作用，并在动物模型和临床环境中定义红细胞在贫血中的内在和/或全身功能障碍及其与CVD的关系。Antioxid。氧化还原信号，26,718-742。
Significance: Recent clinical evidence identified anemia to be correlated with severe complications of cardiovascular disease (CVD) such as bleeding, thromboembolic events, stroke, hypertension, arrhythmias, and inflammation, particularly in elderly patients. The underlying mechanisms of these complications are largely unidentified. Recent Advances: Previously, red blood cells (RBCs) were considered exclusively as transporters of oxygen and nutrients to the tissues. More recent experimental evidence indicates that RBCs are important interorgan communication systems with additional functions, including participation in control of systemic nitric oxide metabolism, redox regulation, blood rheology, and viscosity. In this article, we aim to revise and discuss the potential impact of these noncanonical functions of RBCs and their dysfunction in the cardiovascular system and in anemia. Critical Issues: The mechanistic links between changes of RBC functional properties and cardiovascular complications related to anemia have not been untangled so far. Future Directions: To allow a better understanding of the complications associated with anemia in CVD, basic and translational science studies should be focused on identifying the role of noncanonical functions of RBCs in the cardiovascular system and on defining intrinsic and/or systemic dysfunction of RBCs in anemia and its relationship to CVD both in animal models and clinical settings. Antioxid. Redox Signal. 26, 718–742.