Concentrations of Low-Density Lipoprotein Cholesterol and Total Cholesterol Among Children and Adolescents in the United States
Concentrations of Low-Density Lipoprotein Cholesterol and Total Cholesterol Among Children and Adolescents in the United States
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DOI：
10.1161/circulationaha.108.816769
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发表时间：
2009-03-03
期刊：
影响因子：
37.8
通讯作者：
Mokdad, Ali H.
中科院分区：
文献类型：
--
作者：
Ford, Earl S.;Li, Chaoyang;Mokdad, Ali H.
最近，美国儿科学会更新了儿童血脂筛查指南。我们的目的是检查美国儿童和青少年中总胆固醇和低密度脂蛋白胆固醇浓度的近期分布，并估计可能适合药物治疗低密度脂蛋白胆固醇浓度升高的青少年的患病率。方法和结果我们使用了1999年至2006年国家健康和营养调查的数据，到17岁。12至17岁受试者的低密度脂蛋白胆固醇平均浓度为90.2 mg/dL（n = 2724），6至17岁受试者的总胆固醇平均浓度为163.0 mg/dL（n = 9868）。根据所使用的临界点，5.2%至6.6%的参与者注意到低密度脂蛋白胆固醇浓度升高，9.6%至10.7%的参与者注意到总胆固醇浓度升高。大约0.8%的青少年12至17岁的潜在资格的药物治疗浓度升高的低密度脂蛋白cholesterole.Conclusion鉴于目前的指南，只有一小部分的美国青少年可能需要药物治疗浓度升高的低密度脂蛋白胆固醇。（循环。2009; 119：1108-1115）。
Background Recently, the American Academy of Pediatrics updated guidance on lipid screening in childhood. Our objective was to examine recent distributions in concentrations of total cholesterol and low-density lipoprotein cholesterol among US children and adolescents and to estimate the prevalence of adolescents who are potentially eligible for pharmacological treatment for elevated concentrations of low-density lipoprotein cholesterol.Methods and Results We used data from the National Health and Nutrition Examination Survey 1999 to 2006 for participants 6 to 17 years of age. The mean concentration for low-density lipoprotein cholesterol for participants 12 to 17 years of age was 90.2 mg/dL (n = 2724), and the mean concentration of total cholesterol among participants 6 to 17 years of age was 163.0 mg/dL (n = 9868). Depending on the cut points used, an elevated concentration of low-density lipoprotein cholesterol was noted for 5.2% to 6.6% of participants and an elevated concentration of total cholesterol for 9.6% to 10.7%. Approximately 0.8% of adolescents 12 to 17 years of age were potentially eligible for pharmacological treatment for elevated concentrations of low-density lipoprotein cholesterol.Conclusion Given current guidelines, only a small percentage of US adolescents may need pharmacological treatment for elevated concentrations of low-density lipoprotein cholesterol. (Circulation. 2009; 119: 1108-1115.)