Associations of birthweight and infant growth with body composition at age 15 - the COMPASS study
Associations of birthweight and infant growth with body composition at age 15 - the COMPASS study
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DOI：
10.1111/j.1365-3016.2008.00944.x
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发表时间：
2008-07-01
影响因子：
2.8
通讯作者：
Rasmussen, Finn
中科院分区：
文献类型：
--
作者：
Eriksson, Marit;Tynelius, Per;Rasmussen, Finn
出生时的体型和出生后的生长与成年后的肥胖呈正相关。然而，出生后的生长和身体成分之间的联系在以后的生活中很少被研究。总体目的是探讨出生体重、出生后第一年体重增加与青春期身高、体重、体重指数、无脂肪质量指数（FFMI）、脂肪质量指数、%脂肪质量（FM）和腰围之间的关系。COMPASS研究是一项基于人群的研究，研究对象是瑞典斯德哥尔摩县一个明确地区的青少年。出生特征和儿童时期的体重从登记册和儿童保健中心的记录中收集，15岁时的身体成分由训练有素的护士通过生物电阻抗测量。完整的数据可用于2453名青少年。预测变量和结果变量之间的关联进行了评估与线性回归modeling. Weight呈正相关的所有结果变量，除了%FM女孩。出生体重每增加1 SD，FFMI增加0.49 kg/m2 [95% CI 0.34，0.63]（男孩）和0.25 kg/m2 [0.12，0.38]（女孩）。婴儿期体重增加与身体组成的所有指标都有很强的正相关性。在出生后第一年，体重z评分每增加一个单位，FFMI增加0.73 kg/m2 [0.60，0.87]（男孩）和0.63 kg/m2 [0.50，0.76]（女孩）。婴儿期体重增加的影响不受出生体重的影响。体重和出生后生长均与青春期身体成分呈正相关。在生命的第一年增加体重的影响比产前生长更强，这表明婴儿期是一个更关键的时期。
Size at birth and postnatal growth have been positively associated with obesity in adulthood. However, associations between postnatal growth and body composition later in life have rarely been studied. The overall purpose was to explore the associations between birthweight, weight gain during first year of life and height, weight, body mass index, fat free mass index (FFMI), fat mass index, % fat mass (FM) and waist circumference in adolescence.The COMPASS study is a population-based study of adolescents from a well-defined area in Stockholm County, Sweden. Birth characteristics and weight during childhood were collected from registers and child health centre records, and body composition at age 15 years was measured by bioelectric impedance by trained nurses. Complete data were available for 2453 adolescents. Associations between predictor and outcome variables were assessed with linear regression modelling.Birthweight was positively associated with all outcome variables, except for %FM among girls. FFMI increased by 0.49 kg/m(2) [95% CI 0.34, 0.63] (boys) and 0.25 kg/m(2) [0.12, 0.38] (girls) per 1 SD increase in birthweight. Increased weight gain in infancy showed strong, positive associations with all measures of body composition. FFMI increased by 0.73 kg/m(2) [0.60, 0.87] (boys) and 0.63 kg/m(2) [0.50, 0.76] (girls) per unit increase in weight z-score during first year of life. The effect of increased weight gain in infancy was not modified by birthweight. Birthweight and postnatal growth were both positively related to body composition in adolescence. Increased weight gain during the first year of life had stronger effect than prenatal growth, suggesting infancy to be a more critical period.