Problem or solution: The strange story of glucagon.
Problem or solution: The strange story of glucagon.
复制标题
DOI：
10.1016/j.peptides.2017.11.013
复制
发表时间：
2018-03
期刊：
影响因子：
3
通讯作者：
Bloom SR
中科院分区：
文献类型：
--
作者：
Scott RV;Bloom SR
高胰高血糖素血症见于所有形式的糖尿病，包括2型糖尿病和四氧嘧啶诱导的胰腺破坏。阻断胰高血糖素受体活性的药物正在用于治疗糖尿病的临床试验。正在开发结合胰高血糖素和肠促胰岛素受体的联合收割机活化来治疗肥胖症的肽。在全球范围内，13%的世界成年人口肥胖，超过4亿人患有糖尿病。这些病症都与显著的发病率、死亡率和经济成本相关。因此，寻找新的药物治疗方法势在必行。相对高胰高血糖素血症见于所有类型的糖尿病，并与其发病机制有关。因此，正在进行临床试验，使用阻断胰高血糖素活性的药物治疗2型糖尿病。相反，外源性胰高血糖素可增加能量消耗。因此，研究人员正在设计将胰高血糖素受体的激活与肠促胰岛素特性结合的联合收割机，这将在减轻胰高血糖素的高血糖作用的同时治疗肥胖。这篇综述将讨论胰高血糖素的这些相互矛盾的生理特性，以及利用这些效应的尝试。
Hyperglucagonaemia is seen in all forms of diabetes including type 2 diabetes and alloxan-induced pancreatic destruction. Agents that block activity at the glucagon receptor are being used in clinical trials to treat diabetes. Peptides are being developed which combine activation of glucagon and incretin receptors to treat obesity. Globally, 13% of the world’s adult population is obese, and more than 400 million people suffer from diabetes. These conditions are both associated with significant morbidity, mortality and financial cost. Therefore, finding new pharmacological treatments is an imperative. Relative hyperglucagonaemia is seen in all types of diabetes, and has been implicated in its pathogenesis. Consequently, clinical trials are underway using drugs which block glucagon activity to treat type 2 diabetes. Conversely, exogenous glucagon can increase energy expenditure. Therefore, researchers are designing peptides that combine activation of the glucagon receptor with further incretin properties, which will treat obesity while mitigating the hyperglycaemic effects of glucagon. This review will discuss these conflicting physiological properties of glucagon, and the attempts to harness these effects pharmacologically.
登录
查看更多内容
影响因子：
4.8
作者：
Dakin, CL;Small, CJ;Bloom, SR
通讯作者：
Bloom, SR
影响因子：
4.8
作者：
Dakin, CL;Gunn, I;Bloom, SR
通讯作者：
Bloom, SR
影响因子：
7.7
作者：
Banarer, S;McGregor, VP;Cryer, PE
通讯作者：
Cryer, PE
影响因子：
3.5
作者：
BLACKMAN, B
通讯作者：
BLACKMAN, B
影响因子：
14.8
作者：
Day, Jonathan W.;Ottaway, Nickki;Tschoep, Matthias H.
通讯作者：
Tschoep, Matthias H.