Inflammatory Proteins and the Severity of Dilated Virchow-Robin Spaces in the Elderly
Inflammatory Proteins and the Severity of Dilated Virchow-Robin Spaces in the Elderly
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DOI：
10.3233/jad-2012-120874
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发表时间：
2013-01-01
影响因子：
4
通讯作者：
Tzourio, Christophe
中科院分区：
文献类型：
--
作者：
Satizabal, Claudia L.;Zhu, Yi-Cheng;Tzourio, Christophe
最近的研究表明，扩张的 Virchow-Robin 间隙 (dVRS) 可能是脑小血管疾病的一种表现，但对其危险因素知之甚少。由于炎症与其他脑部 MRI 结果相关，我们研究了白细胞介素 6 和 C 反应蛋白是否与老年人 dVRS 的严重程度相关。对基底神经节和白质进行 dVRS 评估，并按严重程度进行评级。我们发现，白细胞介素 6 水平升高与基底神经节 dVRS 的严重程度较高相关，这表明炎症可能与老年人 dVRS 的负担有关。
Recent studies suggest dilated Virchow-Robin Spaces (dVRS) could be a manifestation of cerebral small-vessel disease, but little is known about their risk factors. As inflammation has been associated with other brain MRI findings, we investigated whether interleukin-6 and C-reactive protein were associated with the severity of dVRS in the eldery. dVRS were assessed in basal ganglia and white matter and rated on a severity scale. We found that elevated interleukin-6 levels were associated with higher severity of dVRS in basal ganglia, suggesting that inflammation might be associated with the burden of dVRS in the elderly.