MicroRNAs as Commanders-in-Chief.
MicroRNAs as Commanders-in-Chief.
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MicroRNA 作为总司令。
DOI：
10.1016/j.jcmgh.2019.09.005
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发表时间：
2020
影响因子：
7.2
通讯作者：
Sáenz,JoséB
中科院分区：
文献类型：
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作者：
Sáenz,JoséB
胃癌是全球癌症相关死亡的主要原因之一，其进展由慢性炎症驱动，并以一系列组织学变化为标志。在这一致癌级联反应中，最早的事件之一涉及胃体中分泌酸的壁细胞和分泌消化酶的主细胞的逐渐丧失，随后分化的有丝分裂后的主细胞重编程为增殖性化生细胞群。这一过程被称为痉挛性多肽表达化生（SPEM），通常代表腺体结构的短暂改变以促进修复，但在慢性损伤时可能导致肿瘤前进展。越来越清楚的是，胃体，像其他胃肠道器官一样，在急性或慢性损伤后表现出显著的修复能力，部分原因是腺上皮细胞的细胞可塑性。主细胞可能是最好的例子，它是一种分化的细胞，可以通过自动降解其分泌机制，重新表达化生标志物并重新进入细胞周期来响应修复的呼吁。[1]然而，这一过程的细胞内机制值得进一步研究。在损伤过程中，主细胞重编程是如何被激活和调节的？哪些主要的细胞特异性基因和途径表征了SPEM的起始和进展？
The progression to gastric cancer, one of the leading causes of cancer-related deaths worldwide, is driven by chronic inflammation and marked by a sequence of histologic changes. One of the earliest events in this oncogenic cascade involves the gradual loss of acidsecreting parietal cells and digestive enzyme-secreting chief cells from the gastric corpus, followed by the reprogramming of differentiated, postmitotic chief cells into a population of proliferative metaplastic cells. This process, termed spasmolytic polypeptide-expressing metaplasia (SPEM), normally represents a transient alteration in the glandular architecture to facilitate repair but can lead to a preneoplastic progression in the face of chronic injury. It is becoming increasingly clear that the gastric corpus, like other gastrointestinal organs, exhibits significant reparative capacity after acute or chronic injury, in part because of the cellular plasticity of glandular epithelial cells. This is perhaps best exemplified by the chief cell, a differentiated cell that can heed the call for repair by autodegrading its secretory machinery, re-expressing metaplastic markers, and re-entering the cell cycle. 1 However, the intracellular mechanisms by which this process unfolds warrant further investigation. How is chief cell reprogramming activated and modulated during injury? What chief cell–specific genes and pathways characterize the initiation and progression to SPEM?