Ki-67 expression is a prognostic marker of prostate cancer recurrence after radical prostatectomy
Ki-67 expression is a prognostic marker of prostate cancer recurrence after radical prostatectomy
复制标题
DOI：
10.1016/s0022-5347(01)65703-3
复制
发表时间：
1996-09-01
影响因子：
6.6
通讯作者：
Moul, JW
中科院分区：
文献类型：
--
作者：
Bettencourt, MC;Bauer, JJ;Moul, JW
目的：我们使用Ki-67抗原的单克隆抗体MIB通过免疫组织化学评估临床局限性前列腺癌的细胞增殖，试图确定根治性前列腺癌切除术后增殖指数和疾病进展之间的关联。奇...应用MIB 1单克隆抗体对180例根治性乳腺癌石蜡包埋标本进行增殖抗原检测，至9岁（平均4.4岁）。测量肿瘤细胞核表达Ki-67抗原的百分比，并分配MIB 1评分（无或罕见阴性，1+-低评分和2 - 4+-高评分），并分析前列腺特异性抗原、分期、年龄、种族、分级和术后血清学复发。
Purpose: We assessed the cellular proliferation of clinically localized prostate cancer by immunohistochemistry using the monoclonal antibody MIB to Ki-67 antigen in an attempt to identify associations between proliferative indexes and disease progression following radical prostatectomy.Materials and Methods: Ki-67 proliferative antigen was evaluated using MIB 1 monoclonal antibody in archival paraffin embedded radical prostatectomy specimens from 180 patients followed for 1 to 9 years (mean 4.4). The percentage of tumor nuclei expressing Ki-67 antigen was measured and assigned an MIB 1 score (none or rare-negative, 1+-low score and 2 to 4+-high score) and analyzed for prostate specific antigen, stage, age, race, grade and serological recurrence postoperatively.Results: There was a significant association between MIB 1 score and nuclear grade (p