Metaplastic Breast Cancer: Clinical Overview and Molecular Aberrations for Potential Targeted Therapy
Metaplastic Breast Cancer: Clinical Overview and Molecular Aberrations for Potential Targeted Therapy
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DOI：
10.1007/s11912-014-0431-z
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发表时间：
2015-03-01
影响因子：
4.7
通讯作者：
Moulder, Stacy
中科院分区：
文献类型：
--
作者：
Abouharb, Sausan;Moulder, Stacy
化生性乳腺癌是一种罕见的浸润性乳腺癌亚型，具有侵袭性，预后差。与标准浸润性导管癌患者相比，全身化疗的反应是次优的。关于最佳治疗方式（包括化疗）的数据有限。本文综述了化生性乳腺癌及其临床和病理特征，以及治疗策略，临床试验和未来的发展方向。
Metaplastic breast cancer is a rare subtype of invasive mammary carcinoma, with an aggressive behavior and usually poor outcome. Responses to systemic chemotherapy are suboptimal compared to patients with standard invasive ductal carcinoma. Limited data are available in regards to best treatment modalities, including chemotherapy. This review gives an overview of metaplastic breast cancer and its clinical and pathologic characteristics, in addition to treatment strategies, clinical trials, and future directions.