A genome-wide association study of DSM-IV cannabis dependence
A genome-wide association study of DSM-IV cannabis dependence
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DOI：
10.1111/j.1369-1600.2010.00255.x
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发表时间：
2011-07-01
影响因子：
3.4
通讯作者：
Bierut, Laura J.
中科院分区：
文献类型：
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作者：
Agrawal, Arpana;Lynskey, Michael T.;Bierut, Laura J.
尽管双胞胎研究表明，DSM-IV大麻依赖的50-70%的变化可归因于遗传影响，但对影响大麻依赖脆弱性的特定基因型知之甚少。我们对DSM-IV大麻依赖进行了全基因组关联研究。使用PLINK中的逻辑回归对708例DSM-IV大麻依赖病例与2346例暴露于大麻的非依赖对照进行关联分析。948 142个单核苷酸多态性中没有一个达到全基因组显著性（P在E-8）。ANKFN 1基因17号染色体多态性（rs 1019238和rs 1431318，E-7处的P值）的P值最低。虽然需要复制，但这项研究代表了澄清大麻依赖的生物学基础的重要的第一步。
Despite twin studies showing that 50-70% of variation in DSM-IV cannabis dependence is attributable to heritable influences, little is known of specific genotypes that influence vulnerability to cannabis dependence. We conducted a genome-wide association study of DSM-IV cannabis dependence. Association analyses of 708 DSM-IV cannabis-dependent cases with 2346 cannabis-exposed non-dependent controls was conducted using logistic regression in PLINK. None of the 948 142 single nucleotide polymorphisms met genome-wide significance (P at E-8). The lowest P values were obtained for polymorphisms on chromosome 17 (rs1019238 and rs1431318, P values at E-7) in the ANKFN1 gene. While replication is required, this study represents an important first step toward clarifying the biological underpinnings of cannabis dependence.