Expression Patterns of ER, HER2, and NM23-H1 in Breast Cancer Patients with Different Menopausal Status Correlations with Metastasis
Expression Patterns of ER, HER2, and NM23-H1 in Breast Cancer Patients with Different Menopausal Status Correlations with Metastasis
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DOI：
10.2165/11590360-000000000-00000
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发表时间：
2011-01-01
影响因子：
4
通讯作者：
Song, Xin
中科院分区：
文献类型：
--
作者：
Dong, Su-Wei;Wang, Lin;Song, Xin
目的：本研究旨在分析雌激素受体（ER）、人表皮生长因子受体-2（hEGF-2）、人表皮生长因子受体（EGF-2）、人（HER 2/ERBB 2）和非转移性蛋白23（NM 23-H1/NME 1）蛋白在浸润性导管癌和不同绝经状态患者中的表达，以确定它们与腋窝淋巴结转移的关系。通过免疫组织化学方法对213名绝经前和177名绝经后诊断为浸润性导管癌的妇女进行ER、HER 2和NM 23-H1蛋白表达的评价。结果：ER表达与绝经状态及淋巴结转移无相关性（均P > 0.05）。绝经前组ER表达与HER 2阴性表达（r =-0.214，p < 0.05）和NM 23-H1阳性表达（r = 0.137，p < 0.05）相关。在ER阴性的绝经后乳腺癌中，HER 2的过度表达与绝经状态（r =-0.107，p < 0.05）和淋巴结转移（r = 0.222，p < 0.05）相关。在ER阳性绝经前组中，NM 23-H1与较少的淋巴结转移相关（r =-0.237，p < 0.05）。我们的研究结果表明，原发性乳腺癌病变中ER、NM 23-H1和HER 2的表达模式警告细胞可能具有转移潜力，这可以帮助临床医生提供更准确的预后并为个体患者定制治疗管理。
Objective: This study was designed to analyze expression patterns of estrogen receptor (ER), human epidermal growth factor receptor-2 (HER2/ERBB2), and nonmetastatic protein 23 (NM23-H1/NME1) proteins in patients with invasive ductal carcinoma and different menopausal status to identify their relationships with axillary lymph node metastasis.Materials and Methods: 213 pre-menopausal and 177 post-menopausal women diagnosed with invasive ductal carcinoma were evaluated for ER, HER2, and NM23-H1 protein expression by immunohistochemistry. When HER2 immunoreactivity was equivocal (category 2+), specimens were confirmed by fluorescence in situ hybridization.Results: ER expression showed no correlation with menopausal status or lymph node metastasis (each p > 0.05). However, expression of ER was associated with negative expression of HER2 (r = -0.214, p < 0.05) and positive expression of NM23-H1 (r = 0.137, p < 0.05) in the pre-menopausal group. Over-expression of HER2 was correlated with menopausal status (r = -0.107, p < 0.05) and lymph node metastasis in the ER-negative post-menopausal group (r = 0.222, p < 0.05). NM23-H1 was associated with less lymph node metastasis in the ER-positive pre-menopausal group (r = -0.237, p < 0.05).Conclusion: Our results indicated that expression patterns of ER, NM23-H1, and HER2 in primary breast cancer lesions warn that cells might have metastatic potential, which could assist clinicians to provide a more accurate prognosis and tailor therapeutic management for individual patients.