Are untimed antiretroviral drug levels useful predictors of adherence behavior?
Are untimed antiretroviral drug levels useful predictors of adherence behavior?
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DOI：
10.1097/00002030-200401020-00017
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发表时间：
2004-01-02
期刊：
影响因子：
3.8
通讯作者：
Bangsberg, DR
中科院分区：
文献类型：
--
作者：
Liechty, CA;Alexander, CS;Bangsberg, DR
我们在83个个体中横断面检查了非定时药物水平与依从性之间的关系。异常低的非定时抗逆转录病毒药物水平对识别在3-5周期间坚持60%或更少药物剂量的个体敏感。异常低的药物水平与较高的病毒载量相关。一个异常低的非定时抗逆转录病毒药物水平可以确定一个人的依从性很低，艾滋病毒疾病进展和死亡的风险很高。
We examined cross-sectionally the relationship between untimed drug levels and adherence in 83 individuals. Abnormally low untimed antiretroviral drug levels were sensitive in identifying individuals adherent to 60% or less of medication doses over a 3-5-week period. An abnormally low drug level was associated with a higher viral load. A single abnormally low untimed antiretroviral drug level can identify an individual with very low adherence at high risk of HIV disease progression and death.