miRNAs regulated by estrogens, tamoxifen, and endocrine disruptors and their downstream gene targets.
miRNAs regulated by estrogens, tamoxifen, and endocrine disruptors and their downstream gene targets.
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DOI：
10.1016/j.mce.2015.01.035
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发表时间：
2015-12-15
影响因子：
4.1
通讯作者：
Klinge CM
中科院分区：
文献类型：
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作者：
Klinge CM
microRNA（miRNAs）是短的（22个核苷酸）、单链、非编码RNA，其与RNA诱导的沉默复合物（RISC）内的靶mRNA的3'非翻译区形成互补碱基对，并阻断翻译和/或刺激mRNA转录物降解。非编码miRBase（2014年6月21日发布）报道，人类基因组包含约2，588种成熟miRNA，其调节约60%的人类蛋白质编码mRNA。miRNA表达失调与雌激素相关疾病（包括乳腺癌和子宫内膜癌）有关。雌激素调节miRNA表达的机制以及雌激素调节的miRNA在正常稳态、生殖、哺乳和癌症中的作用是一个具有巨大研究和临床意义的领域。雌激素通过雌激素受体α和β以组织特异性和细胞依赖性的方式调节miRNAs的转录。本文主要综述了配体激活的ER及其真正的基因靶点对miRNA表达的调控，并包括乳腺癌和细胞系中他莫昔芬和内分泌干扰物（EDCs）对miRNA的调控。
MicroRNAs (miRNAs) are short (22 nucleotides), single-stranded, non-coding RNAs that form complimentary base-pairs with the 3’ untranslated region of target mRNAs within the RNA-induced silencing complex (RISC) and block translation and/or stimulate mRNA transcript degradation. The non-coding miRBase (release 21, June 2014) reports that human genome contains ~2,588 mature miRNAs which regulate ~ 60% of human protein-coding mRNAs. Dysregulation of miRNA expression has been implicated in estrogen-related diseases including breast and endometrial cancers. The mechanism for estrogen regulation of miRNA expression and the role of estrogen-regulated miRNAs in normal homeostasis, reproduction, lactation, and in cancer is an area of great research and clinical interest. Estrogens regulate miRNAs transcription through estrogen receptors α and β in a tissue-specific and cell-dependent manner. This review focuses primary on the regulation of miRNA expression by ligand-activated ERs and their bona fide gene targets and includes miRNAs regulation by tamoxifen and endocrine disrupting chemicals (EDCs) in breast cancer and cell lines.