The differences of hemogram, myelogram, and driver gene mutations in classic myeloproliferative neoplasms
The differences of hemogram, myelogram, and driver gene mutations in classic myeloproliferative neoplasms
复制标题
经典骨髓增生性肿瘤血象、骨髓象和驱动基因突变的差异
DOI：
10.1016/j.bcmd.2022.102698
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发表时间：
2022
影响因子：
2.3
通讯作者：
Zhenya Hong
中科院分区：
文献类型：
--
作者：
Jin Wang;Jin Zhang;Jinjin Huang;Yu Mei;Zhenya Hong
The aim of this study was to explore and compare routine blood features and pathological characteristics of bone marrow tissues in essential thrombocythemia (ET), polycythemia vera (PV), primary myelofibrosis, prefibrotic stage (prePMF) and overt fibrotic stage (overtPMF), and the correlation between common driver gene mutations and clinical manifestations of myeloproliferative neoplasms (MPN). Methods: We analyzed 259 MPN patients treated at Tongji Hospital of Huazhong University of Science and Technology from January 2016 to December 2020. Results: Among ET, PV, prePMF, and overtPMF, the median leukocyte counts of PV and prePMF were significantly higher than those of ET. The average hemoglobin level of overtPMF was significantly lower than that of ET, PV, and prePMF. ET and prePMF had higher platelet counts than PV and overtPMF, whereas ET had the lowest platelet distribution width. Regarding hematopoietic tissues in the bone marrow, enlarged megakaryocytes were easily found in ET, PV, and prePMF, whereas the average diameter of megakaryocytes in prePMF was smaller than in ET, and PV showed various sizes of megakaryocytes. An increased M/E ratio and dilation of sinus were seen more frequently in PMF. Additionally, JAK2-positive patients tended to have significantly higher leukocyte counts than CALR-positive patients in ET and PMF.
