Longitudinal changes in testosterone, luteinizing hormone, and follicle-stimulating hormone in healthy older men
Longitudinal changes in testosterone, luteinizing hormone, and follicle-stimulating hormone in healthy older men
复制标题
DOI：
10.1016/s0026-0495(97)90057-3
复制
发表时间：
1997-04-01
影响因子：
9.8
通讯作者：
Garry, PJ
中科院分区：
文献类型：
--
作者：
Morley, JE;Kaiser, FE;Garry, PJ
横断面研究表明，随着年龄的增长，睾酮以及游离睾酮和生物可利用睾酮会下降，这种情况发生在大多数老年人身上，而促性腺激素（LH）不会增加，这表明睾酮下降的一部分是由于继发性性腺功能减退症。为了确定这些发现是否可以在纵向研究中重复，我们测量了77名男性的睾酮、LH、卵泡刺激素（FSH）和性激素结合球蛋白（SHBG）水平，这些男性参加了新墨西哥州衰老过程研究，他们在1980年或1981年有血清，在1982年、1984年、1989年和/或1994年有两个或更多的系列样本。39例受试者的样本来自1980年和1994年，入组研究时的年龄范围为61 - 87岁。在15年的研究中，睾酮水平下降。在研究期间存活的人中，研究终止前5年的睾酮水平显著较低（P <0.05）。在进入研究时，死亡者和研究结束时存活者的睾酮水平没有差异。77例受试者中有8例（10%）在研究期间的某个时间LH水平高于正常范围。相反，43%的受试者FSH水平升高。LH和FSH均随年龄增长而显著增加，1980年和1994年测量的SHBG水平随年龄增长而显著增加（P <0.0001）。LH和FSH彼此高度相关，但与睾酮均不相关。本研究表明，老年男性睾酮水平呈纵向下降趋势，LH和FSH水平呈上升趋势，睾酮浓度平均每10年下降110 ng/dL。版权所有（C）1997 W.B.桑德斯公司
Cross-sectional studies have demonstrated a decline in testosterone and free and bioavailable testosterone with age, This occurs in a majority of older persons without an increase in luteinizing hormone (LH), suggesting that a component of the testosterone decrease is due to secondary hypogonadism. To determine whether these findings could be duplicated in a longitudinal study, we measured testosterone, LH, follicle-stimulating hormone (FSH), and sex hormone-binding globulin (SHBG) levels in 77 men participating in the New Mexico Aging Process Study who had sera available in 1980 or 1981 and two or more serial samples in 1982, 1984, 1989, and/or 1994. Thirty-nine subjects had samples available from both 1980 and 1994, The age at entry into the study ranged from 61 to 87 years. Testosterone levels decreased over the 15 years of the study. In persons who were alive for the duration of the study, testosterone levels were significantly lower 5 years before termination of the study (P < .05). Testosterone levels did not differ at entry into the study among those who died and those who were alive at the end of the study period. Eight of 77 subjects (10%) had LH levels above the normal range at some time during the study. In contrast, 43% of subjects had elevated FSH levels. Both LH and FSH increased significantly with age, SHBG levels were measured in 1980 and 1994 and increased significantly with age (P < .0001). LH and FSH were highly correlated with one another, but neither correlated with testosterone. This study demonstrated a longitudinal decline in testosterone and an increase in LH and FSH in older men, The average rate of decrement in testosterone concentration was 110 ng/dL every decade. Copyright (C) 1997 by W.B. Saunders Company.