Alkenenitrile Transmissive Olefination: Synthesis of the Putative Lignan "Morinol I"
Alkenenitrile Transmissive Olefination: Synthesis of the Putative Lignan "Morinol I"
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DOI：
10.1002/ejoc.201101235
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发表时间：
2011-12-01
影响因子：
2.8
通讯作者：
Ravikumar, P. C.
中科院分区：
文献类型：
--
作者：
Fleming, Fraser F.;Liu, Wang;Ravikumar, P. C.
Grignard试剂引发与α ′-羟基丙烯腈的加成-消除反应以选择性地生成Z-烯腈。由格氏试剂、丙烯腈和醛形成的Z-烯腈的模块化组装是立体选择性合成烯烃的理想方法，如推定的木脂素桑酚I的合成所示。
Grignard reagents trigger an additionelimination with a'-hydroxy acrylonitriles to selectively generate Z-alkenenitriles. The modular assembly of Z-alkenenitriles from a Grignard reagent, acrylonitrile, and an aldehyde is ideal forstereoselectively synthesizing alkenes, as illustrated in the synthesis of the putative lignan morinol I.