Anticancer and Cancer Chemopreventive Potential of Grape Seed Extract and Other Grape-Based Products
Anticancer and Cancer Chemopreventive Potential of Grape Seed Extract and Other Grape-Based Products
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DOI：
10.3945/jn.109.106864
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发表时间：
2009-09-01
影响因子：
4.2
通讯作者：
Agarwal, Rajesh
中科院分区：
文献类型：
--
作者：
Kaur, Manjinder;Agarwal, Chapla;Agarwal, Rajesh
随着各种器官部位癌症发病率的出现趋势，需要额外的方法来控制人类恶性肿瘤。通过膳食成分干预或预防癌症，一种被定义为化学预防的策略，在我们控制癌症的征服中具有很大的希望，因为它可以在更广泛的人口基础上实施，经济负担更小。与此相一致，一些流行病学研究表明，食用富含水果和蔬菜的饮食的人群总体癌症发病率较低。基于这些令人鼓舞的观察结果，来自地球仪的研究工作集中在识别、表征各种植物营养素的功效并为其提供科学依据，以努力开发控制各种人类恶性肿瘤的有效策略。癌症的诱导、生长和进展是多步骤的事件，许多研究已经证明，各种饮食制剂干扰癌症的这些阶段，从而阻断恶性肿瘤。水果和蔬菜是各种营养和非营养植物化学物质的未开发的水库，具有潜在的癌症化学预防活性。葡萄和以葡萄为基础的产品就是这样一类饮食产品，它们已经显示出癌症化学预防的潜力，并且也被认为可以改善人类的整体健康。本文综述了近年来葡萄籽提取物及其衍生物在癌症化学预防和抗癌方面的研究进展。总的来说，来自不同科学团体的完整研究得出结论，葡萄和以葡萄为基础的产品都是各种抗癌药物的良好来源，因此经常食用它们对普通人群有益。
With emerging trends in the incidence of cancer of various organ sites, additional approaches are needed to control humanmalignancies. Intervention or prevention of cancer by dietary constituents, a strategy defined as chemoprevention, holdsgreat promise in our conquest to control cancer, because it can be implemented on a broader population base with lesseconomic burden. Consistent with this, several epidemiological studies have shown that populations that consume dietsrich in fruits and vegetables have an overall lower cancer incidence. Based on these encouraging observations, researchefforts from across the globe have focused on identifying, characterizing, and providing scientific basis to the efficacy ofvarious phytonutrients in an effort to develop effective strategy to control various human malignancies. Cancer induction,growth, and progression are multi-step events and numerous studies have demonstrated that various dietary agentsinterfere with these stages of cancer, thus blocking malignancy. Fruits and vegetables represent untapped reservoir ofvarious nutritive and nonnutritive phytochemicals with potential cancer chemopreventive activity. Grapes and grape-basedproducts are one such class of dietary products that have shown cancer chemopreventive potential and are also known toimprove overall human health. This review focuses on recent advancements in cancer chemopreventive and anticancerefficacy of grape seed extract and other grape-based products. Overall, completed studies from various scientific groupsconclude that both grapes and grape-based products are excellent sources of various anticancer agents and their regularconsumption should thus be beneficial to the general population.