The development and innervation of transplanted limb primordia of chick embryos
The development and innervation of transplanted limb primordia of chick embryos
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DOI：
10.1002/jez.1400800302
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发表时间：
1939-04-01
影响因子：
--
通讯作者：
Hamburger, V
中科院分区：
文献类型：
--
作者：
Hamburger, V
鸡胚（48 ~ 72小时）的翅原基和后肢原基。的孵化）移植到侧翼或体腔的宿主胚胎的相同阶段。149例（=25%）移植物发育为正常肢体。对其中32例进行了神经支配研究。移植物的神经支配来自肢体神经或躯干神经或两者的组合。有证据表明，“吸引”的力量，引导向外生长的神经向移植。向内生长的神经在进入移植物之前形成神经丛;它们在移植物内形成正常的神经模式，而不管它们的来源和数量。他们的distr。很明显是dtd。由分化肢的结构决定。移植神经表现出明确但有限的增生。在许多病例中发现了能动性。无神经和神经支配不良的肢体发育正常。它们的形态发生是独立的神经支配，因此，功能。
Wing and hind limb primordia of chick embryos (48 to 72 hrs. of incubation) were transplanted to the flank or into the coelom of host embryos of the same stages. In 149 cases (=25%) the transplants developed into normal limbs. Their innervation was studied in 32 cases. Transplants received their innervation from limb nerves or from trunk nerves or from a combination of both. Evidence was given for "attractive" forces which guide the outgrowing nerves toward the transplant. The ingrowing nerves formed a plexus before entering the transplant; they formed a normal nerve pattern within the transplant irrespective of their origin and their quantity. Their distr. was evidently detd. by the structures of the differentiating limb. Transplant nerves showed a definite but limited hyperplasia. Motility was found in numerous cases. Nerveless and poorly innervated limbs developed normally. Their morphogenesis was independent of innervation and, consequently, of function.