TRICHINELLA-SPIRALIS - MEDIATION OF THE INTESTINAL COMPONENT OF PROTECTIVE IMMUNITY IN THE RAT BY MULTIPLE, PHASE-SPECIFIC, ANTI-PARASITIC RESPONSES
TRICHINELLA-SPIRALIS - MEDIATION OF THE INTESTINAL COMPONENT OF PROTECTIVE IMMUNITY IN THE RAT BY MULTIPLE, PHASE-SPECIFIC, ANTI-PARASITIC RESPONSES
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DOI：
10.1016/0014-4894(79)90068-7
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发表时间：
1979-01-01
影响因子：
2.1
通讯作者：
DESPOMMIER, DD
中科院分区：
文献类型：
--
作者：
BELL, RG;MCGREGOR, DD;DESPOMMIER, DD
经口感染T.旋毛虫产生了一种免疫力，这种免疫力是由寄生虫肠道生命周期的不同阶段诱导和表达的。感染性肌幼虫产生针对极早期肠道感染的免疫应答（快速排出），并导致在24小时内排出蠕虫。该反应消除了经口攻毒接种物中95%以上的蠕虫。发育中的幼虫（前成虫）诱导针对蠕虫的免疫应答。对成虫的影响取决于蠕虫在其肠内幼虫发育过程中持续暴露于免疫环境。成虫前T.对从非免疫大鼠转移的蠕虫，螺旋体不表达。虽然蠕虫对前成虫产生的免疫力有抵抗力，但它们诱导了自身特异性的有效免疫力。成虫前和成虫免疫表现为蠕虫繁殖力的抑制和成虫从肠道中排出。这2种反应的动力学和对各种蠕虫负荷的效率不同。成虫前免疫主要针对生殖力，而成虫免疫有利于蠕虫驱逐。所有的反应（快速驱逐，成年前和成年免疫和抗繁殖）协同作用，产生无菌免疫力对挑战感染高达5000肌肉幼虫。宿主对T.螺旋体可能是一个复杂的多因素过程，顺序和协同作用，以保护宿主免受再感染。
Rats infected orally with T. spiralis developed an immunity that was induced by and expressed against separate phases of the parasite''s enteral life cycle. Infectious muscle larvae generated an immune response (rapid expulsion) that was directed against the very early intestinal infection and resulted in the expulsion of worms within 24 h. This response eliminated more than 95% of worms in an oral challenge inoculum. Developing larvae (pre-adults) induced an immune response that was expressed against adult worms. The effect on adults was dependent upon continuous exposure of worms to the immune environment throughout their enteral larval development. Immunity induced by pre-adult T. spiralis was not expressed against adult worms transferred from nonimmune rats. While adult worms were resistant to the immunity engendered by pre-adults they induced an efficient immunity that was autospecific. Pre-adult and adult immunities were expressed in depression of worm fecundity and in the expulsion of adults from the gut. The 2 reactions differed in respect to their kinetics and their efficiency against various worm burdens. Pre-adult immunity was directed mainly against fecundity whereas adult immunity favored worm expulsion. All responses (rapid expulsion, pre-adult and adult immunity and anti-fecundity) acted synergistically to produce sterile immunity against challenge infections of up to 5000 muscle larvae. The host protective response to T. spiralis may be a complex, multifactorial process that operates sequentially and synergistically to protect the host against reinfection.