Estimating the passage of minutes: deviant oscillatory frontal activity in medicated and unmedicated ADHD.
Estimating the passage of minutes: deviant oscillatory frontal activity in medicated and unmedicated ADHD.
复制标题
估计分钟的流逝：药物和未药物多动症中异常的振荡额叶活动。
DOI：
10.1037/a0034032
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发表时间：
2013
期刊：
影响因子：
2.4
通讯作者：
Wetzel,MartinW
中科院分区：
文献类型：
--
作者：
Wilson,TonyW;Heinrichs-Graham,Elizabeth;White,MatthewL;Knott,NicholeL;Wetzel,MartinW
注意力缺陷/多动障碍（ADHD）是一种常见的和广泛治疗的儿童精神疾病，通常持续到成年。核心诊断症状包括不适当水平的多动、冲动和/或普遍注意力不集中。这种疾病的另一个重要方面涉及时间知觉的畸变，这在行为研究中已有很好的记录，最近也成为神经影像学研究的焦点。这些功能性磁共振成像研究表明，减少激活前扣带和前额叶皮质在多动症使用的时间间隔歧视的任务，使参与者区分间隔不同的只有几百milliseconds.MethodWe使用脑磁图（MEG）来评估皮质网络服务的时间感知在一个连续的，长时间（分钟）的时间估计实验。简单地说，用药和未用药的ADHD患者以及对照组在两次单独的MEG会议中每次估计60秒过去时都做出反应，时间不详。所有的MEG数据转换成区域源activity，并进行频谱分析，以获得伽玛波段activity.ResultsCompared的幅度估计，未用药的患者是不太准确的时间估计，并有较弱的伽玛活动在前扣带回，补充运动区，左前额叶皮层。药物治疗后，这些患者表现出小，但在这些相同的神经区域和时间估计的准确性，这与γ活动increases.ConclusionWe相关的显着改善伽马增加小，但显着的增加发现不足的γ活动在大脑中已知的是至关重要的计时功能，这可能是一天到一天的异常时间知觉是常见的ADHD。（PsycInfo数据库记录（c）2022阿帕，保留所有权利）
ObjectiveAttention-deficit/hyperactivity disorder (ADHD) is a common and extensively treated psychiatric disorder in children, which often persists into adulthood. The core diagnostic symptoms include inappropriate levels of hyperactivity, impulsivity, and/or pervasive inattention. Another crucial aspect of the disorder involves aberrations in temporal perception, which have been well documented in behavioral studies and, recently, have been the focus of neuroimaging studies. These functional magnetic resonance imaging studies have shown reduced activation in anterior cingulate and prefrontal cortices in ADHD using a time-interval discrimination task, whereby participants distinguish intervals differing by only hundreds of milliseconds.MethodWe used magnetoencephalography (MEG) to evaluate the cortical network serving temporal perception during a continuous, long-duration (in minutes) time estimation experiment. Briefly, medicated and unmedicated persons with ADHD, and a control group responded each time they estimated 60 s had elapsed for an undisclosed amount of time in two separate MEG sessions. All MEG data were transformed into regional source activity, and subjected to spectral analyses to derive amplitude estimates of gamma-band activity.ResultsCompared to controls, unmedicated patients were less accurate time estimators and had weaker gamma activity in the anterior cingulate, supplementary motor area, and left prefrontal cortex. After medication, these patients exhibited small but significant increases in gamma across these same neural regions and significant improvements in time estimation accuracy, which correlated with the gamma activity increases.ConclusionWe found deficient gamma activity in brain areas known to be crucial for timing functions, which may underlie the day-to-day abnormalities in time perception that are common in ADHD.(PsycInfo Database Record (c) 2022 APA, all rights reserved)