PONTINE CONTROL OF THE URINARY-BLADDER AND EXTERNAL URETHRAL SPHINCTER IN THE RAT
PONTINE CONTROL OF THE URINARY-BLADDER AND EXTERNAL URETHRAL SPHINCTER IN THE RAT
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DOI：
10.1016/0006-8993(90)91758-9
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发表时间：
1990-11-05
期刊：
影响因子：
2.9
通讯作者：
DEGROAT, WC
中科院分区：
文献类型：
--
作者：
KRUSE, MN;NOTO, H;DEGROAT, WC
人所共知的是，在控制排尿方面，脑桥顶部被盖的神经元起着重要作用。本实验采用乌拉坦麻醉大鼠，观察电刺激桥脑不同部位对膀胱和外括约肌活动的影响以及对尿量阈值的影响。刺激被盖背外侧核、导水管周围灰质或臂旁外侧核的短脉冲串(50 Hz，1~3个S串，1~15V)可引起部分充盈的静止膀胱收缩。然而，膀胱收缩时的刺激终止了收缩，这表明这些区域既有抑制作用，也有兴奋作用。在膀胱测压过程中，持续刺激PAG或L旁路区(50赫兹)可减少膀胱容量(平均减少36%)。相反，持续刺激桥脑网状结构(在蓝核背侧核和臂旁内侧核或其附近)可增加膀胱容量(平均增加50%)。刺激桥脑(Ldt、PAG和L旁旁核)引起膀胱收缩，也引起尿外括约肌活动增加。在膀胱扩张引起的反射性排尿过程中，尿路括约肌活性也有类似的增加。这些数据表明，大鼠的膀胱容量以及膀胱和外尿路功能的协调性受大鼠头侧脑桥不同神经元群的控制。
Neurons in the rostral pontine tegmentum are known to have an important role in controlling micturition. The present experiments used urethane anesthetized rats to examine the effects of electrical stimulation at various sites in the pons on bladder and external urethral sphincter activity and on the volume threshold for inducing micturition. Stimulation with short trains of pulses (50 Hz, 1-3 s trains, 1-15 V) in the laterodorsal tegmental nucleus (LDT), the periaqueductal grey (PAG) or the lateral parabrachial nucleus (L-PBN) elicited contractions of a partially filled, quiescent bladder. However stimulation during a bladder contraction aborted the contraction indicating that these areas have inhibitory as well as excitatory effects. Continuous stimulation (50 Hz) in the PAG or L-PBN during a cystometrogram decreased bladder capacity (mean decrease 36%). Conversely, continuous stimulation in the pontine reticular formation (in or near the dorsal subcoeruleus nucleus and medial parabrachial nucleus) increased bladder capacity (mean increase 50%). Stimulation at pontine sites (LDT, PAG and L-PBN) which elicited bladder contractions also elicited an increase in external urethral sphincter activity. A similar increase in urethral sphincter activity occurred during reflex micturition induced by bladder distension. These data suggest that bladder capacity and the coordination of bladder and external urethral functions are controlled by various neuronal population in the rostral pons of the rat.