I. HISTORICAL DATA
I. HISTORICAL DATA
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DOI：
10.1111/j.1749-6632.1963.tb53765.x
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发表时间：
1963-02
影响因子：
5.2
通讯作者：
N. Michels
中科院分区：
文献类型：
--
作者：
N. Michels
我..。活的颗粒细胞：肥大细胞的发现和早期历史与我们对结缔组织的早期知识有关。大多数最初的研究都是在活组织上进行的。粗大颗粒的细胞由于其血管周围的栖息地和细胞质的显著多态，在许多情况下无疑是组织肥大细胞的代表。以这种非特定的方式，v.Reckinghausen(1863)~Kuhne(1864)、Koelliker(1867)、Friedlander(1867)、Cohnheim(1869)、Rollett(1871)、Schobl(1871)和Flemming(1876)可以被共同视为肥大细胞的发现者。Kiihne在青蛙肌肉间组织中的分裂细胞样结构的图形无疑代表了肥大细胞。正如Westphal后来所展示的那样，弗里德兰德在青蛙心脏中的“神经节细胞”也是如此。兰维尔于1869年首次尝试用现代方法对结缔组织细胞进行分类。通过皮卡红染色，他选择了“细胞板”作为结缔组织的主要细胞形式，这是一种扁平的、孤立的、原生质差的细胞类型。
I . Living granulated cells: HE discovery and early history of the mast cell is associated with our T early knowledge of connective tissue. Most of the initial investigations were made on living tissues. Cells with coarse granules were reported which, because of their perivascular habitat and marked polymorphism of cytoplasm, in many instances undoubtedly represented tissue mast cells. In this non-specific manner v. Recklinghausen ( 1 8 6 3 ) ~ Kuhne ( 1 864) , Koelliker (1867) , Friedlander (1867) , Cohnheim (1869) , Rollett (1871), Schobl (1871), and Flemming (1876) may be regarded collectively as the discoverers of the mast cell. Kiihne’s figures of clasmatocyte-like structures in the intermuscular tissue of frog unquestionably represent mast cells. The same may be said of Friedlander’s “ganglion cells” in the heart of frog as subsequently shown by Westphal. The first attempt to classify connective-tissue cells in a modern way was made by Ranvier in (1869). With picro-carmine staining he selected as the chief cellular form of connective tissue the “cellule plate,” a cell type that was flat, isolated and poor in protoplasm.