SWISS-MODEL and the Swiss-PdbViewer: An environment for comparative protein modeling
SWISS-MODEL and the Swiss-PdbViewer: An environment for comparative protein modeling
复制标题
DOI：
10.1002/elps.1150181505
复制
发表时间：
1997-12-01
期刊：
影响因子：
2.9
通讯作者：
Peitsch, MC
中科院分区：
文献类型：
--
作者：
Guex, N;Peitsch, MC
比较蛋白质建模越来越受到人们的关注，因为它在诱变实验的合理设计过程中有很大的帮助。然而，这种方法的可用性以及由此产生的模型受到昂贵的计算机硬件和软件的可用性的限制。为了克服这些局限性，我们已经开发了一个比较蛋白质建模的环境，包括SWISS-MODEL，自动比较蛋白质建模的服务器和SWISS-PdbViewer，序列结构工作台。Swiss-PdbViewer不仅作为SWISS-MODEL的客户端，还提供了大量的结构分析和显示工具。此外，我们还提供SWISS-MODEL Repository，这是一个包含3500多个自动生成的蛋白质模型的数据库。通过向科学界免费提供这些工具，我们希望在实验设计过程中增加蛋白质结构和模型的使用。
Comparative protein modeling is increasingly gaining interest since it is of great assistance during the rational design of mutagenesis experiments. The availability of this method, and the resulting models, has however been restricted by the availability of expensive computer hardware and software. To overcome these limitations, we have developed an environment for comparative protein modeling that consists of SWISS-MODEL, a server for automated comparative protein modeling and of the SWISS-PdbViewer, a sequence to structure workbench. The Swiss-PdbViewer not only acts as a client for SWISS-MODEL, but also provides a large selection of structure analysis and display tools. In addition, we provide the SWISS-MODEL Repository, a database containing more than 3500 automatically generated protein models. By making such tools freely available to the scientific community, we hope to increase the use of protein structures and models in the process of experiment design.