Catecholamine-induced alteration in sedimentation behavior of membrane bound beta-adrenergic receptors.
Catecholamine-induced alteration in sedimentation behavior of membrane bound beta-adrenergic receptors.
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儿茶酚胺诱导膜结合β-肾上腺素能受体沉降行为的改变。
DOI：
10.1126/science.6254143
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发表时间：
1980
期刊：
影响因子：
--
通讯作者：
Perkins,JP
中科院分区：
文献类型：
--
作者：
Harden,TK;Cotton,CU;Waldo,GL;Lutton,JK;Perkins,JP
星形细胞瘤细胞与儿茶酚胺一起孵育会导致儿茶酚胺刺激的腺苷酸环化酶活性降低，并随之改变颗粒 β-肾上腺素能受体的沉降特性。改变的受体表现出与与腺苷酸环化酶“解偶联”的受体类似的激动剂结合特性。
Incubation of astrocytoma cells with catecholamines results in a decrease in catecholamine-stimulated adenylate cyclase activity and a concomitant alteration in the sedimentation properties of particulate β-adrenergic receptors. The altered receptors exhibit agonist binding properties similar to those of receptors that are "uncoupled" from adenylate cyclase.