Effect of resistance training on rat skeletal muscle during severe food restriction
Effect of resistance training on rat skeletal muscle during severe food restriction
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严格限食期间阻力训练对大鼠骨骼肌的影响
DOI：
10.1002/tsm2.162
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发表时间：
2020
影响因子：
1.2
通讯作者：
Fujita Satoshi
中科院分区：
文献类型：
--
作者：
Sase Kohei;Kido Kohei;Ato Satoru;Fujita Satoshi
骨骼肌质量是通过持续的肌肉蛋白质合成和分解来维持的。食物限制增加肌肉蛋白质分解，从而导致肌肉质量损失。模拟肌肉收缩（RE）的急性抗阻运动减弱了禁食诱导的蛋白质分解。我们假设三次RE（阻力训练：RT）减轻了食物限制引起的肌肉蛋白质分解和随后的肌肉萎缩。将24只11周龄雄性Sprague-道利大鼠分为两组（标准饮食组（C）;平均摄食量的30%组（FR））。通过经皮电刺激右侧腓肠肌进行RE，左侧腓肠肌被指定为久坐腿。RE每两天进行一次，共进行三次。在FR组中，与C组相比，两条腿的肌纤维横截面积（CSA）均降低（P<0.05）。此外，仅在FR组中，与久坐腿相比，运动倾向于降低运动腿的CSA（P= 0.09）。FR可降低rpS 6的表达（P<0.05），FR组未出现RE诱导的rpS 6表达增加。我们得出结论，RT不能防止大鼠中食物限制引起的肌肉质量损失。
Skeletal muscle mass is maintained by continuous muscle protein synthesis and breakdown. Food restriction augments muscle protein breakdown and consequently induces muscle mass loss. Acute bouts of resistance exercise mimicking muscle contractions (RE) attenuate fasting‐induced protein breakdown. We hypothesized that three bouts of RE (resistance training: RT) attenuate food restriction‐induced muscle protein breakdown and subsequent muscle atrophy. Twenty‐four 11‐week‐old male Sprague‐Dawley rats were divided into two groups (standard diet group (C); 30% of the average amount of food consumed group (FR)). RE was conducted by percutaneous electrical stimulation of the right gastrocnemius muscle, and the left gastrocnemius muscle was assigned as the sedentary leg. RE was performed once every two days with a total of three sessions. In the FR group, the muscle fiber cross‐sectional area (CSA) was decreased compared with that in the C group in both legs (P< .05). Furthermore, only in the FR group, exercise tended to decrease CSA of the exercised leg compared to that of the sedentary leg (P= .09). The expression of rpS6 was decreased by FR (P< .05), and RE‐induced increase of rpS6 expression did not occur in the FR group. We conclude that RT did not prevent food restriction‐induced muscle mass loss in rats.
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影响因子：
21.3
作者：
通讯作者：
--
影响因子：
3.3
作者：
Mizushima, N;Yamamoto, A;Ohsumi, Y
通讯作者：
Ohsumi, Y
一次抗阻运动对严重禁食后骨骼肌蛋白质代谢的影响
影响因子：
2.5
作者：
Sase Kohei;Kido Kohei;Ato Satoru;Fujita Satoshi
通讯作者：
Fujita Satoshi
影响因子：
3.3
作者：
Kotani, Takaya;Takegaki, Junya;Ishii, Naokata
通讯作者：
Ishii, Naokata
影响因子：
3.3
作者：
Reljic, Dejan;Haessler, Eike;Friedmann-Bette, Birgit
通讯作者：
Friedmann-Bette, Birgit