Non-invasive Access to the Vagus Nerve Central Projections via Electrical Stimulation of the External Ear: fMRI Evidence in Humans.
Non-invasive Access to the Vagus Nerve Central Projections via Electrical Stimulation of the External Ear: fMRI Evidence in Humans.
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DOI：
10.1016/j.brs.2014.11.018
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发表时间：
2015-05
影响因子：
7.7
通讯作者：
Komisaruk, Barry R.
中科院分区：
文献类型：
--
作者：
Frangos, Eleni;Ellrich, Jens;Komisaruk, Barry R.
关键词：
猫和大鼠迷走神经耳支(ABVN)投射到孤束核(NTS)的追踪研究表明，ABVN在人类是否投射到NTS尚不清楚。为了确定非侵入性电刺激外耳甲(ABVN专有支配的外耳区域)是否激活了人类的NTS和“经典”中央迷走神经投射。12名健康成年人在同一时间接受了两次fMRI扫描。对耳垂(对照组，扫描1)和左耳甲(扫描2)进行电刺激(连续0.25ms脉冲，25 Hz)。采用FSL软件进行统计分析。我们进行了两个兴趣区分析，以测试耳甲刺激(与基线和对照、耳垂、刺激相比)对中央迷走神经投射的影响(校正后；脑干P<；0.01，前脑P<；0.05)，随后进行全脑分析(校正后，P<；0.05)。与耳垂(对照)刺激相比，耳甲刺激可显著激活“经典”中枢迷走神经投射，如同侧孤束核、双侧三叉神经脊束核、中缝背核、蓝斑、对侧臂旁区、杏仁核和伏隔核的广泛活动。中心旁小叶的双侧激活也被观察到。在双侧的海马体和下丘脑观察到失活。这些发现在人类身上提供了证据，证明ABVN的中央投射与经典的迷走神经中央投射是一致的，并且可以通过外耳非侵入性地进入。
Tract-tracing studies in cats and rats demonstrated that the auricular branch of the vagus nerve (ABVN) projects to the nucleus tractus solitarii (NTS); it has remained unclear as to whether or not the ABVN projects to the NTS in humans. To ascertain whether non-invasive electrical stimulation of the cymba conchae, a region of the external ear exclusively innervated by the ABVN, activates the NTS and the “classical” central vagal projections in humans. Twelve healthy adults underwent two fMRI scans in the same session. Electrical stimulation (continuous 0.25ms pulses, 25Hz) was applied to the earlobe (control, scan #1) and left cymba conchae (scan #2). Statistical analyses were performed with FSL. Two region-of-interest analyses were performed to test the effects of cymba conchae stimulation (compared to baseline and control, earlobe, stimulation) on the central vagal projections (corrected; brainstem p<0.01, forebrain p<0.05), followed by a whole-brain analysis (corrected, p< 0.05). Cymba conchae stimulation, compared to earlobe (control) stimulation, produced significant activation of the “classical” central vagal projections, e.g., widespread activity in the ipsilateral nucleus of the solitary tract, bilateral spinal trigeminal nucleus, dorsal raphe, locus coeruleus, and contralateral parabrachial area, amygdala, and nucleus accumbens. Bilateral activation of the paracentral lobule was also observed. Deactivations were observed bilaterally in the hippocampus and hypothalamus. These findings provide evidence in humans that the central projections of the ABVN are consistent with the “classical” central vagal projections and can be accessed non-invasively via the external ear.
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影响因子：
5.7
作者：
Jenkinson, M;Bannister, P;Smith, S
通讯作者：
Smith, S
影响因子：
9.9
作者：
Henry, TR;Votaw, JR;Hoffman, JM
通讯作者：
Hoffman, JM
影响因子：
5.6
作者：
Henry, TR;Bakay, RAE;Hoffman, JM
通讯作者：
Hoffman, JM
DOI：
10.1515/bmt.2008.022
发表时间：
2008-01-01
期刊：
BIOMEDIZINISCHE TECHNIK
影响因子：
--
作者：
Dietrich, Stefan;Smith, James;Ringler, Ralf
通讯作者：
Ringler, Ralf
影响因子：
9.9
作者：
Kirchner, A;Birklein, F;Handwerker, HO
通讯作者：
Handwerker, HO