Vascular resistance of carotid and vertebral arteries is associated with retinal microcirculation measured by laser speckle flowgraphy in patients with type 2 diabetes mellitus
Vascular resistance of carotid and vertebral arteries is associated with retinal microcirculation measured by laser speckle flowgraphy in patients with type 2 diabetes mellitus
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2型糖尿病患者颈动脉和椎动脉的血管阻力与激光散斑血流成像测量的视网膜微循环有关
DOI：
10.1016/j.diabres.2020.108240
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发表时间：
2020
影响因子：
5.1
通讯作者：
Kunikat
中科院分区：
文献类型：
--
作者：
Sawada Shojiro;Tsuchiya Satoko;Kodama Shinjiro;Kurosawa Satoko;Endo Akira;Sugawara Hiroto;Hosaka Shinichiro;Kawana Yohei;Asai Yoichiro;Yamamoto Junpei;Munakata Yuichiro;Izumi Tomohito;Takahashi Kei;Kaneko Keizo;Imai Junta;Ito Azusa;Yasuda Masayuki;Kunikat
视网膜微循环的评价是了解视网膜血管病变，如糖尿病视网膜病变的关键。激光散斑血流图（LSFG）最近使我们能够直接评估血管阻力在视网膜血管和毛细血管，非侵入性。因此，我们评估视网膜血管血流和/或毛细血管微循环是否与糖尿病患者颈部动脉血流无严重retinopathy.MethodsWe纳入110例2型糖尿病患者，没有或轻度非增殖性糖尿病视网膜病变，在这个前瞻性横断面研究。我们测量的电阻率指数（RI）的视网膜血管和毛细血管的LSFG和颈部动脉的多普勒超声，然后通过分析associations.ResultsThe RI不仅颈动脉，而且椎动脉与视网膜血管血流和视网膜毛细血管微循环。多元回归分析显示，这些协会是独立的其他解释变量，包括年龄和糖尿病duration.ConclusionsWe获得了新的和直接的证据表明糖尿病患者的视网膜微循环和颈动脉血流动力学之间的密切联系。这些发现表明，共同的机制，微和大血管病变的基础。因此，颈部动脉的高血管阻力可能是发生视网膜病变的风险。
AimsEvaluation of the retinal microcirculation is key to understanding retinal vasculopathies, such as diabetic retinopathy. Laser speckle flowgraphy (LSFG) has recently enabled us to directly evaluate the vascular resistance in both retinal vessels and capillaries, non-invasively. We therefore assessed whether retinal vessel blood flow and/or the capillary microcirculation are associated with blood flow in the cervical arteries in diabetic patients without severe retinopathy.MethodsWe enrolled 110 type 2 diabetes patients, with no or mild non-proliferative diabetic retinopathy, in this prospective cross-sectional study. We measured the resistivity indices (RIs) of the retinal vessel and capillaries by LSFG and those of cervical arteries by Doppler ultrasonography, followed by analyzing associations.ResultsThe RIs of not only the carotid but also vertebral arteries were associated with those of retinal vessel blood flow and the retinal capillary microcirculation. Multiple regression analyses revealed these associations to be independent of other explanatory variables including age and diabetes duration.ConclusionsWe obtained novel and direct evidence demonstrating a close association between the retinal microcirculation and cervical artery hemodynamics in diabetic patients. These findings suggest shared mechanisms to underlie micro- and macro-angiopathies. Thus, high vascular resistance of cervical arteries may be a risk of developing retinopathy.