Experimental and engineering approaches to intracellular communication.
Experimental and engineering approaches to intracellular communication.
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DOI：
10.1042/ebc20180024
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发表时间：
2018-10-26
影响因子：
6.4
通讯作者：
Davies AE
中科院分区：
文献类型：
--
作者：
Albeck JG;Pargett M;Davies AE
细胞之间和细胞内的交流对多细胞生命至关重要。虽然细胞内信号转导途径通常在分子方面进行了详细说明，但它们传递的信息内容仍然定义不清。在这里，我们回顾了将生物实验与从信号处理和控制理论的工程学科中出现的通信概念相结合的研究工作。我们讨论了在分子水平上量化信息传递的实验所面临的挑战，并强调了最近的研究，这些研究已经朝着更清晰地定义信号分子所携带的信息内容的方向发展。在这些研究中，我们强调了一个主题，即越来越匹配的实验和理论方法来解码指导细胞行为的数据流。
Communication between and within cells is essential for multicellular life. While intracellular signal transduction pathways are often specified in molecular terms, the information content they transmit remains poorly defined. Here, we review research efforts to merge biological experimentation with concepts of communication that emerge from the engineering disciplines of signal processing and control theory. We discuss the challenges of performing experiments that quantify information transfer at the molecular level, and we highlight recent studies that have advanced toward a clearer definition of the information content carried by signaling molecules. Across these studies, we emphasize a theme of increasingly well-matched experimental and theoretical approaches to decode the data streams directing cellular behavior.