PHARMACOLOGICAL CHARACTERIZATION OF A MODIFIED SOCIAL-INTERACTION MODEL OF ANXIETY IN THE RAT
PHARMACOLOGICAL CHARACTERIZATION OF A MODIFIED SOCIAL-INTERACTION MODEL OF ANXIETY IN THE RAT
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DOI：
10.1159/000118187
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发表时间：
1985-01-01
影响因子：
3.2
通讯作者：
GARDNER, CR
中科院分区：
文献类型：
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作者：
GUY, AP;GARDNER, CR
两个不熟悉的雄性大鼠在昏暗的灯光下，熟悉的环境之间的社会互动（SI）已被调查的焦虑模型，其中新奇的合作伙伴仍然是主要的焦虑刺激。在这种情况下，已经测试了一系列中枢作用药物。在所述模型中，利血平、硝西泮、氟硝西泮和泮均增加SI，丁螺环酮、CL 218872、舒立克隆、丙戊酸钠和烟酰胺也是如此。促炎剂FG 7142和育亨宾降低SI，而不显著改变运动活动。然而，兴奋剂安非他明增加了这种情况下的所有行为。安非他明也增加了所有的行为时，大鼠进行了测试，与他们的笼，当欲望的SI在很大程度上是满足。CL 218872在第二种情况下也增加了SI，这表明该药物在本试验中的作用可能具有非特异性成分。此外，咖啡因、茶碱和吡拉西坦在该模型中也可能具有非特异性行为作用。
Social interaction (SI) between two unfamiliar male rats in a dimly lit, familiar environment has been investigated as a model of anxiety, where novelty of the partner remains as the principal anxiogenic stimulus. A range of centrally acting drugs have been tested in this situation. Chlordiazepoxide, nitrazepam, flunitrazepam, and flurazepam all increase SI, as does buspirone, CL 218872, suriclone, sodium valproate, and nicotinamide in the model described. Anxiogenic agents FG 7142 and yohimbine reduced SI without significant modification of motor activities. However, the stimulant amphetamine increased all behaviours in this condition. Amphetamine also increased all behaviours when rats were tested with their cagemates, when the desire for SI is largely satiated. CL 218872 also increased SI in this second situation and it is suggested that this agent may have a non-specific component in its action in this test. Additionally, caffeine, theophylline, and piracetam may also have non-specific behavioural actions in this model.