Voxel-based morphometry of grey matter densities in subjects at high risk of schizophrenia
Voxel-based morphometry of grey matter densities in subjects at high risk of schizophrenia
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DOI：
10.1016/s0920-9964(03)00158-0
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发表时间：
2003-11-01
影响因子：
4.5
通讯作者：
Lawrie, SM
中科院分区：
文献类型：
--
作者：
Job, DE;Whalley, HC;Lawrie, SM
采用基于体素的形态测量技术（VBM）对精神分裂症高危患者（n = 146）与正常对照（n = 36）和首发精神分裂症患者（n = 34）的T1期脑结构磁共振（MR）图像中的灰质（GM）片段进行比较。受试者是为爱丁堡高风险研究（EHRS）招募的，区域脑容量之前已经使用半自动体积感兴趣区（ROI）分析方法进行了测量。对于当前的报告，使用研究特定的模板处理图像，并使用SPM99程序进行统计分析。SPM中的小体积校正工具也用于将分析限制在特定体素上。双侧前扣带灰质（GM）密度的概率降低，在高风险受试者与对照组相比，在左侧海马旁回呈下降趋势。相比之下，首发精神分裂症患者在几个额叶和颞叶区域的GM少于高危患者。这些结果与我们之前的体积ROI分析结果一致。(C) 2003 Elsevier B.V.版权所有
The grey matter (GM) segments from T1 structural magnetic resonance (MR) images of the brain in subjects at high risk of schizophrenia (n = 146) were compared with normal control subjects (n = 36) and first episode schizophrenic subjects (n = 34) using automated voxel-based morphometry (VBM). The subjects were recruited for the Edinburgh High Risk Study (EHRS) and regional brain volumes had previously been measured using a semi-automated volumetric region of interest (ROI) method of analysis. For the current report, the images were processed using a study specific template and statistically analysed using the SPM99 program. The small volume correction tool in SPM was also used to restrict the analyses to specific voxels. Reductions in the probability of grey matter (GM) density were seen bilaterally in the anterior cingulate, and as a trend in the left parahippocampal gyrus for the high-risk vs. control subjects. In contrast, first episode schizophrenia subjects had less GM than high-risk subjects in several frontal and temporal regions. These results are compatible with the findings of our previous volumetric ROI analysis. (C) 2003 Elsevier B.V. All rights reserved.