Prevalence of the metabolic syndrome and its relation to all-cause and cardiovascular mortality in nondiabetic European men and women
Prevalence of the metabolic syndrome and its relation to all-cause and cardiovascular mortality in nondiabetic European men and women
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DOI：
10.1001/archinte.164.10.1066
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发表时间：
2004-05-24
影响因子：
--
通讯作者：
Pyorala, K
中科院分区：
文献类型：
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作者：
Hu, G;Qiao, Q;Pyorala, K
背景：很少有研究评估代谢综合征（任何定义）和死亡率之间的关系。本研究探讨了年龄和性别特异性的代谢综合征的患病率及其与非糖尿病的欧洲男性和女性的全因和心血管死亡率的相关性。方法：本研究是基于11个前瞻性的欧洲队列研究，包括6156名男性和5356名女性无糖尿病，年龄从30岁至89岁，并有一个中位数为8.8年的后续行动。使用了世界卫生组织对代谢综合征定义的修改。如果受试者存在高胰岛素血症和以下2种或2种以上情况，则认为其患有代谢综合征：肥胖、高血压、血脂异常或葡萄糖调节受损;然而，还研究了其他定义。采用考克斯模型估计每个队列的全因死亡率和心血管死亡率的风险比。进行荟萃分析，以评估整体关联的代谢综合征与死亡risk.Results：年龄标准化患病率的代谢综合征是略高于男性（15.7%）比女性（14.2%）。在随访期间记录的1119例死亡中，432例是由心血管疾病引起的。代谢综合征患者与非代谢综合征患者相比，全因死亡率和心血管死亡率的总体风险比为1.44（95%置信区间[CI]，1.17-1.84）和2.26（95% CI，1.61-3.17）男性和1.38（95% CI，1.02-1.87）和2.78（95%CI，1.57-4.94）在调整年龄、血胆固醇水平和吸烟后的女性中。在非糖尿病的欧洲成年人中，代谢综合征的总患病率为15%。患有代谢综合征的非糖尿病患者因各种原因以及心血管疾病而死亡的风险增加。
Background: Few studies have evaluated the associations between the metabolic syndrome (by any definition) and mortality. This study examined the age- and sex-specific prevalence of the metabolic syndrome and its association with all-cause and cardiovascular mortality in nondiabetic European men and women.Methods: The study was based on 11 prospective European cohort studies comprising 6156 men and 5356 women without diabetes and aged from 30 to 89 years, and had a median follow-up of 8.8 years. A modification of the World Health Organization definition of the metabolic syndrome was used. The subjects were considered to have the metabolic syndrome if they had hyperinsulinemia and 2 or more of the following: obesity, hypertension, dyslipidemia, or impaired glucose regulation; however, other definitions were also studied. Hazard ratios for all-cause and cardiovascular mortality were estimated with Cox models in each cohort. Meta-analyses were performed to assess the overall association of the metabolic syndrome with mortality risk.Results: The age-standardized prevalence of the metabolic syndrome was slightly higher in men (15.7%) than in women (14.2%). Of the 1119 deaths recorded during follow-up, 432 were caused by cardiovascular disease. The overall hazard ratios for all-cause and cardiovascular mortality in persons with the metabolic syndrome compared with persons without it were 1.44 (95% confidence interval [CI], 1.17-1.84) and 2.26 (95% CI, 1.61-3.17) in men and 1.38 (95% CI, 1.02-1.87) and 2.78 (95% CI, 1.57-4.94) in women after adjustment for age, blood cholesterol levels, and smoking.Conclusions: The overall prevalence of the metabolic syndrome in nondiabetic adult Europeans is 15%. Nondiabetic persons with the metabolic syndrome have an increased risk of death from all causes as well as cardiovascular disease.