DIET AND THE EXCRETION AND ENTEROHEPATIC CYCLING OF ESTROGENS
DIET AND THE EXCRETION AND ENTEROHEPATIC CYCLING OF ESTROGENS
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DOI：
10.1016/0091-7435(87)90067-3
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发表时间：
1987-07-01
影响因子：
5.1
通讯作者：
GOLDIN, BR
中科院分区：
文献类型：
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作者：
GORBACH, SL;GOLDIN, BR
对绝经前和绝经后进食不同饮食的妇女进行了尿便排泄和血浆雌激素水平的测定。当绝经前的美国妇女吃含有高脂肪(40%的卡路里)和低纤维的“西方饮食”时，与吃中脂肪(30%)、高纤维饮食的同龄素食者相比，发现素食者的粪便中的雌激素排泄量增加了三倍，尿液排泄量减少，血浆雌激素水平降低了15%-20%。当将美国绝经前和绝经后的女性与最近吃非常低脂肪饮食(卡路里的20%-25%)的亚洲移民进行比较时，得到了类似的结果，只是东方人的血浆雌激素水平比西方杂食性女性低30%。膳食成分与血浆雌激素的相关分析表明，血浆雌激素与脂肪呈正相关，与纤维呈负相关。结果表明，饮食可以通过影响肠-肝循环改变雌激素的分泌途径，进而影响血浆雌激素水平。
Urinary and fecal excretion and plasma levels of estrogens were measured in pre- and postmenopausal women eating different diets. When premenopausal U.S. women eating a “Western diet,” comprising high fat (40% of calories) and low fiber, were compared with age-matched vegetarians eating a moderate-fat (30%), high-fiber diet, it was found that the vegetarians excreted threefold more estrogen in their feces, had lower urinary excretion, and had 15–20% lower plasma estrogen levels. When U.S. pre- and postmenopausal women eating a Western diet were compared with recent Asian immigrants eating a very low-fat diet (20–25% of calories), similar results were obtained except that plasma estrogen levels were 30% lower among Orientals compared with those among Western omnivore women. Correlation analysis of dietary components and plasma estrogen showed that plasma estrogen was positively associated with fat and was negatively associated with fiber. The results indicate that diet can alter the route of excretion of estrogen by influencing the enterohepatic circulation and that this, in turn, influences plasma estrogen levels.