SARS-CoV-2 Seroprevalence and Symptom Onset in Culturally Linked Orthodox Jewish Communities Across Multiple Regions in the United States.
SARS-CoV-2 Seroprevalence and Symptom Onset in Culturally Linked Orthodox Jewish Communities Across Multiple Regions in the United States.
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DOI：
10.1001/jamanetworkopen.2021.2816
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发表时间：
2021-03-01
影响因子：
13.8
通讯作者：
Silverberg JI
中科院分区：
文献类型：
--
作者：
Zyskind I;Rosenberg AZ;Zimmerman J;Naiditch H;Glatt AE;Pinter A;Theel ES;Joyner MJ;Hill DA;Lieberman MR;Bigajer E;Stok D;Frank E;Silverberg JI
严重急性呼吸道综合征冠状病毒2（SARS-CoV-2）的爆发能否在文化上受限制的少数民族社区同时发生？在这项对9507名非卧床成年人的横断面研究中，在地理上不同但文化上受约束的宗教社区中，发现多达32.5%的社区成员中2019年冠状病毒病症状发作和高血清阳性率几乎同时激增。这一激增与普珥节周围的社会事件相对应，在流行病缓解策略得到广泛认可之前。这些研究结果表明，在节日期间，在文化上受约束的社区内可能会发生平行的疫情，如果没有国家的、对文化敏感的指导，这种情况可能会加剧。这项横断面研究阐明了美国5个州的一个文化相关的正统犹太社区中严重急性呼吸道综合征冠状病毒2型（SARS-CoV-2）血清阳性率和2019年冠状病毒病（COVID-19）症状的发病情况。关于美国严重急性呼吸综合征冠状病毒2型（SARS-CoV-2）血清阳性率的数据仍在不断涌现。阐明SARS-CoV-2在美国5个州的文化联系社区中的血清阳性率和症状发作。这项横断面研究纳入了2020年5月13日至7月6日期间从美国3个不同地理区域的5个州（加州、康涅狄格州、密歇根州、新泽西和纽约）的正统犹太社区招募的成人（年龄≥18岁）。参与者完成了在线调查，并接受了SARS-CoV-2抗体检测。SARS-CoV-2的血清阳性率和症状发作日期。总体而言，9507名成人（平均[SD]年龄，39.6 [15.0]岁; 3777名[39.7%]女性）完成了SARS-CoV-2调查，其中6665名（70.1%）接受了免疫球蛋白G抗SARS-CoV-2抗体水平评估。在所有社区都观察到SARS-CoV-2抗体的高血清阳性率，在新泽西（3323人中有1080人[32.5%]）和纽约（2196人中有671人[30.6%]）观察到的阳性检测比例最高。大多数SARS-CoV-2免疫球蛋白G抗体检测阳性的个体报告的SARS发病日期为2020年3月9日至3月31日（加州：154人中的135人[87.7%];康涅狄格州：34人中的32人[94.1%];密歇根州：50人中的44人[88.0%];新泽西：1168人中的964人[82.5%];纽约：571/677 [84.3%]）。这一开始日期与2020年3月9日至10日庆祝的犹太节日普林节相吻合，在随后的几周内（症状发作高峰期的平均值和模式，2020年3月20日），在没有强有力的一般和特定文化的公共卫生指令的情况下发生了广泛的内部传播。这项对美国各地正统犹太成年人的横断面研究发现，社会文化约束的社区在离散的地点经历了早期的平行爆发，特别是在实质性的医疗和政府指令之前。进一步的研究应该澄清最佳的国家，地方，社区和政府政策，以防止在传统上聚集在假日，集会和节日的社会和文化社区爆发。
Can severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreaks occur simultaneously across culturally bound minority communities? In this cross-sectional study of 9507 ambulatory adults, a near simultaneous surge in coronavirus disease 2019 symptom onset and high seroprevalence in as many as 32.5% community members were found among geographically distinct yet culturally bound religious communities. This surge corresponded to social events surrounding the festival of Purim, prior to widespread recognition of epidemic mitigation strategies. These findings suggest that parallel outbreaks may occur within culturally bound communities during holiday periods, which could be exacerbated in the absence of national, culturally sensitive guidance. This cross-sectional study elucidates the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) seroprevalence and onset of coronavirus disease 2019 (COVID-19) symptoms in a culturally linked orthodox Jewish community across 5 US states. Data on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) seroprevalence in the United States are still emerging. To elucidate SARS-CoV-2 seroprevalence and symptom onset in a culturally linked community across 5 states in the United States. This cross-sectional study included adults (aged ≥18 years) recruited from the orthodox Jewish community across 5 states (California, Connecticut, Michigan, New Jersey, and New York) in 3 geographically distinct areas of the United States between May 13 and July 6, 2020. Participants completed an online survey and underwent SARS-CoV-2 antibody testing. Seroprevalence and date of symptom onset of SARS-CoV-2. Overall, 9507 adults (mean [SD] age, 39.6 [15.0] years; 3777 [39.7%] women) completed the SARS-CoV-2 survey, of whom 6665 (70.1%) had immunoglobin G anti–SARS-CoV-2 antibody levels assessed. A high seroprevalence of SARS-CoV-2 antibodies was observed across all communities, with the highest proportion of positive testing observed in New Jersey (1080 of 3323 [32.5%]) and New York (671 of 2196 [30.6%]). Most individuals with a positive SARS-CoV-2 immunoglobin G antibody test reported a date of symptom-onset between March 9 and March 31, 2020 (California: 135 of 154 [87.7%]; Connecticut: 32 of 34 [94.1%]; Michigan: 44 of 50 [88.0%]; New Jersey: 964 of 1168 [82.5%]; New York: 571 of 677 [84.3%]). This start date was coincident with the Jewish festival of Purim, celebrated March 9 to 10, 2020, with extensive intracommunity spread in the weeks following (mean and mode of peak symptom onset, March 20, 2020), occurring in the absence of strong general and culture-specific public health directives. This cross-sectional study of orthodox Jewish adults across the US found that socioculturally bound communities experienced early parallel outbreaks in discrete locations, notably prior to substantive medical and governmental directives. Further research should clarify optimal national, local, community-based, and government policies to prevent outbreaks in social and cultural communities that traditionally gather for holidays, assemblies, and festivals.
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DOI：
10.15585/mmwr.mm6918e2
发表时间：
2020-05-08
期刊：
MMWR. Morbidity and mortality weekly report
影响因子：
--
作者：
Schuchat A;CDC COVID-19 Response Team
通讯作者：
CDC COVID-19 Response Team
影响因子：
9.4
作者：
Theel, Elitza S.;Harring, Julie;Granger, Dane
通讯作者：
Granger, Dane
DOI：
10.4103/ijciis.ijciis_60_20
发表时间：
2020-04-01
影响因子：
--
作者：
Miller, Andrew C;Castro Bigalli, Alberto A;Sumanam, Phanniram
通讯作者：
Sumanam, Phanniram
影响因子：
33.9
作者：
Hamner, Lea;Dubbel, Polly;Leibrand, Howard
通讯作者：
Leibrand, Howard
影响因子：
7.4
作者：
Elmore, Joann G.;Wang, Pin-Chieh;Currier, Judith S.
通讯作者：
Currier, Judith S.