Cancer stem cell signaling pathways.
Cancer stem cell signaling pathways.
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DOI：
10.1097/md.0000000000004765
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发表时间：
2016-09
期刊：
影响因子：
1.6
通讯作者：
Matsui WH
中科院分区：
文献类型：
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作者：
Matsui WH
组织发育和体内平衡是由干细胞的作用控制的。多能细胞能够在人的一生中自我更新。准确、恰当地调控干细胞功能对正常的生物活性至关重要。几个关键的发育或信号通路已被证明在这种调节能力中发挥重要作用。具体来说，janus激活的激酶/信号转导和转录激活因子、Hedgehog、Wnt、Notch、磷脂酰肌醇3-激酶/磷酸酶和紧张素同源物以及核因子κ b信号通路都被实验证明可以介导各种干细胞特性，如自我更新、细胞命运决定、存活、增殖和分化。不出所料，许多这些关键的信号通路在癌症中失调。越来越多的证据表明，这些通路内部和之间的信号过度活跃或异常可能有助于癌症干细胞（CSCs）的存活。干细胞是一种相对罕见的癌细胞群，能够自我更新、分化，并产生一系列可移植的异质肿瘤。
Tissue development and homeostasis are governed by the actions of stem cells. Multipotent cells are capable of self-renewal during the course of one's lifetime. The accurate and appropriate regulation of stem cell functions is absolutely critical for normal biological activity. Several key developmental or signaling pathways have been shown to play essential roles in this regulatory capacity. Specifically, the Janus-activated kinase/signal transducer and activator of transcription, Hedgehog, Wnt, Notch, phosphatidylinositol 3-kinase/phosphatase and tensin homolog, and nuclear factor-κB signaling pathways have all been shown experimentally to mediate various stem cell properties, such as self-renewal, cell fate decisions, survival, proliferation, and differentiation. Unsurprisingly, many of these crucial signaling pathways are dysregulated in cancer. Growing evidence suggests that overactive or abnormal signaling within and among these pathways may contribute to the survival of cancer stem cells (CSCs). CSCs are a relatively rare population of cancer cells capable of self-renewal, differentiation, and generation of serially transplantable heterogeneous tumors of several types of cancer.