NERVE CONDUCTION AND OTHER STUDIES IN FAMILIES WITH CHARCOT-MARIE-TOOTH DISEASE
NERVE CONDUCTION AND OTHER STUDIES IN FAMILIES WITH CHARCOT-MARIE-TOOTH DISEASE
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DOI：
10.1093/brain/87.4.589
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发表时间：
1964-01-01
期刊：
影响因子：
14.5
通讯作者：
VINCENT, BL
中科院分区：
文献类型：
--
作者：
MYRIANTHOPOULOS, NC;LANE, MH;VINCENT, BL
方法我们能够进行传导速度测量的胫前神经和尺神经在这些家庭的97名成员。在恒温条件下，在三组个体中进行测量：（1）直系亲属中未发生疾病的未受影响的个体;（2）受影响父母的未受影响的子女;和（3）受影响的个体。所有接受传导测试的人，以及许多没有接受测试的人，都接受了神经系统检查。用于测量胫前神经和尺神经的运动纤维的传导速度的方法与Hodes等人描述的方法基本相同。（1948）和Lambert（1956）。通过双通道肌电图仪和刺激器，通过最大电刺激在膝关节和踝关节（胫前神经）和肘关节和腕关节（尺神经）诱发动作电位。这些信号分别由趾短伸肌和小鱼际肌上的表面电极采集。在阴极射线示波器上记录刺激和反应的时刻，并对其进行拍照和测量。传导时间以米每秒为单位计算，方法是将两点之间的距离除以连续刺激两点时肌肉的反应潜伏期。
METHODSWe were able to perform conduction velocity measurements of the anterior tibial and ulnar nerves in 97 members of these families. The measurements were taken, under constant temperature conditions, in three groups of individuals:(1) unaffected individuals among whose immediate relatives the disease had not occurred;(2) unaffected children of affected parents; and (3) affected individuals. All individuals who underwent conduction tests, and many who were not tested, were given a neurological examination. The method used to measure the conduction velocity of the motor fibres of the anterior tibial and ulnar nerves was substantially the same as that described by Hodes et al.(1948) and Lambert (1956). By means of a dual-channel electromyograph and stimulator, action potentials were evoked by maximal electrical stimulation at the knee and ankle (for the anterior tibial nerve) and elbow and wrist (for the ulnar nerve). These were picked up by a surface electrode over the extensor digitorum brevis and hypothenar muscles respectively. The moments of stimulation and response were recorded on a cathode-ray oscilloscope where they were photographed and measured. The conduction time was calculated in metres per second by dividing the distance between two points by the latency of response of the muscle when the two points were successively stimulated.